An enzyme immunoassay with homologous and heterologous antigens has been elaborated for the diagnosis of clonorchiasis. 251 blood serum samples from patients with clonorchiasis have been studied, as well as 230 samples from patients with geohelminthiases obtained from North Vietnam provinces and 299 samples from Moscow donors. The test sensitivity and specificity were 78.72% and 94.52%, respectively. The dependence of test sensitivity on the intensity of infection has been noted. The calculation of the diagnostic value of enzyme immunoassay makes it possible to use it with respect to the level of the population invaxon: in low level of invaxon (below 32%) D = 2.11M + 0.06, in invaxon level above 32%, D = 1.74M + 0.04. The use of a homologous antigen enhances the test sensitivity.
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