AI Article Synopsis
- The study examines the antibiotic resistance of 55 anaerobic Gram-negative bacteria linked to human infections, specifically from patients with chronic periodontitis.
- All strains of Fusobacterium nucleatum were vulnerable to several antibiotics, but some showed resistance to amoxicillin and clarithromycin.
- Prevotella strains also exhibited susceptibility to certain antibiotics, yet a number were resistant to amoxicillin and other medications, highlighting the need for better lab tests to guide treatment and reduce antibiotic misuse.
Article Abstract
In view of the increasing antibiotic resistance of anaerobic Gram-negative bacteria, we determined the antimicrobial profile of 55 periodontal anaerobic Gram-negative bacteria correlated with human infections, comprising 16 strains of Fusobacterium nucleatum and 39 strains of Prevotella spp. isolated from periodontal pockets of 26 adults suffering from chronic periodontitis. All the strains of F. nucleatum were susceptible to amoxicillin/clavulanic acid, doxycycline, metronidazole, moxifloxacin and levofloxacin, whilst 2/16 strains were both resistant to amoxicillin and beta-lactamase-positive and 11/16 were resistant to clarithromycin. All of the Prevotella strains were susceptible to amoxicillin/clavulanic acid, doxycycline and metronidazole, whereas 7/39 strains were beta-lactamase-positive and resistant to amoxicillin, 5/39 were resistant to clarithromycin and 3/39 were resistant to both moxifloxacin and levofloxacin. Our findings confirm that there is an increasing need to encourage practitioners to use laboratory investigations to limit the risk of an incorrect therapeutic approach and to avoid the overuse of antimicrobial agents.
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| http://dx.doi.org/10.1016/j.ijantimicag.2007.07.022 | DOI Listing |
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