AI Article Synopsis
- Survivors of childhood acute lymphoblastic leukemia (ALL) face the risk of second malignancies, especially brain tumors like meningiomas, particularly in those treated with cranial irradiation.
- Meningiomas are the most prevalent second neoplasms in these patients, while breast cancer can occur alongside meningioma but isn't believed to result from ALL treatment.
- The text covers the molecular genetics and treatment of childhood ALL, examines meningioma's genetic aspects, and explores the potential link between meningioma and breast cancer.
Article Abstract
Second malignancies are a significant concern for survivors of childhood acute lymphoblastic leukemia (ALL), in particular patients who have been treated with cranial irradiation. Brain tumors, most commonly meningiomas, are among the most common second neoplasms discovered in these patients. Breast cancer can occur in association with meningioma, but is not thought to be a consequence of treatment for childhood ALL. We describe the molecular genetics and therapy of childhood ALL, the molecular genetics of meningioma, as well as the possible association between meningioma and breast cancer.
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| http://dx.doi.org/10.4161/cbt.6.10.4928 | DOI Listing |
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