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A fuzzy physiologically based pharmacokinetic modeling framework to predict drug disposition in humans. | LitMetric

A fuzzy physiologically based pharmacokinetic modeling framework to predict drug disposition in humans.

Conf Proc IEEE Eng Med Biol Soc

Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.

Published: March 2008

AI Article Synopsis

Article Abstract

To date, the application of physiologically based pharmacokinetic (PBPK) models in support of drug discovery remains limited, in part due to information deficit and uncertainty regarding model parameters. Fuzzy set theory provides a suitable way to objectively account for parameter uncertainty in models. Here, we present a fuzzy set-based PBPK modeling framework and demonstrate its utility in predicting diazepam pharmacokinetics in human plasma, following intravenous dosing, from available animal in vivo and literature data. For computationally expensive PBPK models, the sparse grid method is proposed as an efficient alternative to commonly used fuzzy arithmetic algorithms for function simulation.

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Source
http://dx.doi.org/10.1109/IEMBS.2006.259383DOI Listing

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