The accurate boundary extraction is an essential preprocessing step for computerized analysis of a breast ultrasonic image. In this study, a novel approach based on the wavelet transform and the dynamic programming is proposed to extract tumor boundaries from breast ultrasonic images. Firstly, a rectangular region-of-interest (ROI) is manually selected from the ultrasonic image, followed by the ROI-based preprocessing for the noise reduction and image enhancement. Then an initial boundary of the tumor is obtained using the wavelet transform. To achieve a more accurate result, a dynamic programming algorithm based on the active contour model is applied to adjust the initial boundary. Experiments on 45 breast ultrasonic images have shown that this proposed method is a promising technique for the boundary extraction of breast tumor on ultrasonic images.
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http://dx.doi.org/10.1109/IEMBS.2006.260597 | DOI Listing |
Anal Chem
January 2025
Department of Biomedical Engineering, Lund University, Lund SE-223 63, Sweden.
Isolation and characterization of circulating tumor cells (CTCs) present a noninvasive alternative to monitor disease progression in individual patients. However, the heterogeneous lineage specificity of CTCs makes it difficult to isolate and identify possible CTCs by a liquid biopsy. Better label-free methods for the isolation of viable CTCs are needed.
View Article and Find Full Text PDFTheranostics
January 2025
Cancer Research Center, School of Medicine, Xiamen University, Xiamen, 361102, China.
Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonodynamic therapy (SDT), aimed at enhancing the efficacy of programmed cell death protein 1 (PD-1) inhibitors by inducing robust ICD responses.
View Article and Find Full Text PDFSci Prog
January 2025
Oncology Department, Affiliated Wuxi Fifth People's Hospital of Jiangnan University, Wuxi, Jiangsu, PR China.
Cell division cycle-associated (CDCA) genes are dysregulated in carcinomas. Our study aims to identify similarities and differences of the clinical roles of CDCAs in breast cancer (BRCA) and to explore their potential mechanisms. In GEPIA, compared to normal tissues, expressions of CDCAs were higher in BRCA and sub-types.
View Article and Find Full Text PDFAm J Cancer Res
December 2024
Department of General Surgery, Liaoning University of Traditional Chinese Medicine Affiliated Hospital Shenyang 110032, Liaoning, China.
The involvement of axillary lymph nodes (ALNs) is a critical prognostic factor affecting patient management and outcomes in breast cancer (BC). This study aims to comprehensively analyze the clinical data of BC patients, evaluate ultrasonic signs of ALNs, and explore the implications of a prediction model for ALN metastasis (ALNM) in early-stage BC patients based on ultrasonic features and clinical data. This study retrospectively analyzed ultrasonic features and clinical data from 216 patients diagnosed with unilateral invasive BC.
View Article and Find Full Text PDFEur Radiol
January 2025
Department of Information Technology, Uppsala University, 75237, Uppsala, Sweden.
Objectives: The aim is to assess the feasibility and accuracy of a novel quantitative ultrasound (US) method based on global speed-of-sound (g-SoS) measurement using conventional US machines, for breast density assessment in comparison to mammographic ACR (m-ACR) categories.
Materials And Methods: In a prospective study, g-SoS was assessed in the upper-outer breast quadrant of 100 women, with 92 of them also having m-ACR assessed by two radiologists across the entire breast. For g-SoS, ultrasonic waves were transmitted from varying transducer locations and the image misalignments between these were then related analytically to breast SoS.
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