In this paper we report on results from experiments performed on a bi-modal piezoelectric transducer used both as an active ultrasound transceiver and a passive acoustic sensor. The transducer, which has a low Q factor in order to exhibit a sufficiently broad bandwidth, will be integrated into a wearable system. In particular, it is placed, along with ECG fabric electrodes, within a textile belt wrapped around the chest. The transducer behaves as an acoustic sensor at low frequency and as an ultrasound transducer at high frequency. The low-frequency acoustic signals were compared with the analogue signals acquired simultaneously by commercial biomedical sensors. These signals provide information about the respiratory activity and heart apex pulse. A comparative analysis was performed both in the time and frequency domain and results were discussed. Moreover, the same transducer used at high frequencies is able to generate ultrasound signals which can bounce off the target organ, the heart, and receive the back-propagated echoes. The experimental validation was done by means of a comparison between the spatial interval inferred from time delay of the return echoes detected by the transducer and the actual distance from the target. This information, in addition to ECG signals, can provide helpful cues for the cardiac status of the subject, both in terms of prevention and diagnosis.
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http://dx.doi.org/10.1109/IEMBS.2006.260453 | DOI Listing |
Ultrasonics
January 2025
Centre for Medical & Industrial Ultrasonics, James Watt School of Engineering, University of Glasgow, Glasgow, UK. Electronic address:
A new focussed ultrasound surgery (FUS) transducer for soft tissue ablation is proposed, with a miniaturised configuration that can be readily integrated with a surgical robot. The transducer fills a gap in FUS technology at this size, with capability for acoustic focus steering within a very simple transducer configuration. Miniaturisation is enabled by the incorporation of an acoustic Fresnel lens as the focussing element driven by a single piezoceramic disc.
View Article and Find Full Text PDFJ Neural Eng
January 2025
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Transcranial ultrasound stimulation (TUS) presents challenges in ultrasound wave transmission through the skull, affecting study outcomes due to aberration and attenuation. While planning strategies incorporating 3D computed tomography (CT) scans help mitigate these issues, they expose participants to radiation, which can raise ethical concerns. A solution involves generating skull masks from participants' anatomical magnetic resonance imaging (MRI).
View Article and Find Full Text PDFNat Commun
January 2025
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Acoustically probing biological tissues with light or sound, photoacoustic and ultrasound imaging can provide anatomical, functional, and/or molecular information at depths far beyond the optical diffusion limit. However, most photoacoustic and ultrasound imaging systems rely on linear-array transducers with elevational focusing and are limited to two-dimensional imaging with anisotropic resolutions. Here, we present three-dimensional diffractive acoustic tomography (3D-DAT), which uses an off-the-shelf linear-array transducer with single-slit acoustic diffraction.
View Article and Find Full Text PDFJ Med Chem
January 2025
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892 United States.
Angew Chem Int Ed Engl
January 2025
University of Science and Technology of China School of Biomedical Engineering, Department of Polymer Science and Engineering, 96 Jinzhai Road, 230026, Hefei, CHINA.
Lipid nanoparticles (LNPs) based messenger RNA (mRNA) therapeutics hold immense promise for treating a wide array of diseases, while their nonhepatic organs targeting and insufficient endosomal escape efficiency remain challenges. For LNPs, polyethylene glycol (PEG) lipids have a crucial role in stabilizing them in aqueous medium, but they severely hinder cellular uptake and reduce transfection efficiency. In this study, we designed ultrasound (US)-assisted fluorinated PEGylated LNPs (F-LNPs) to enhance spleen-targeted mRNA delivery and transfection.
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