A national audit of the management of first episode genital herpes (GH) was undertaken by non-consultant career grade doctors working in genitourinary (GU) medicine clinics in the United Kingdom. In total, 1620 data collection forms were completed (794 men and 826 women). Virus culture is the main detection method (1150, 71%), although polymerase chain reaction (PCR) use is increasing (442, 28%). PCR was significantly associated (P<0.0001) with fewer negative isolates (29/442, 6.6%) compared with virus culture (174/1150, 15%). Herpes simplex virus type 1 was isolated in 552 cases (46%). For 243 cases (15%), there was no evidence of counselling about GH. A total of 1355 (84%) were screened for other sexually transmitted infections. Serological testing for syphilis was undertaken in 72%. GU medicine clinics are managing first episode GH as broadly outlined in the guidelines. Areas identified for improvement are to increase counselling/written information/testing for syphilis towards 100%.
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http://dx.doi.org/10.1258/095646207782193740 | DOI Listing |
Environ Monit Assess
January 2025
Department of Life and Consumer Sciences, University of South Africa, Johannesburg, South Africa.
Exploring drought dynamics has become urgent due to unprecedented climate change. Projections indicate that drought events will become increasingly widespread globally, posing a significant threat to the sustainability of the agricultural sector. This growing challenge has resulted in heightened interest in understanding drought dynamics and their impacts on agriculture.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
From the Department of Radiology, University of Bourgogne Franche-Comté, CHRU Besançon, 3 boulevard Alexandre Fleming, Besançon 25030, France.
Subpial hemorrhage (SPH) is a rare but significant cause of neonatal seizures and respiratory distress, primarily affecting full-term infants without apparent risk factors. We report the case of a full-term newborn who presented with recurrent episodes of apnea, desaturation, and seizures shortly after birth. MRI revealed an acute hemorrhagic collection in the left temporal region, accompanied by cortical cytotoxic edema.
View Article and Find Full Text PDFJ Hum Reprod Sci
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine Airlangga University, Airlangga University Hospital, Surabaya, Indonesia.
Background: Recurrent pregnancy loss (RPL) often stems from a hypercoagulable state that exacerbates conditions such as antiphospholipid syndrome (APS) and thrombophilia, leading to early placental issues. Although treatments such as low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) are used, outcomes vary. This study proposes using first-trimester Doppler ultrasound - specifically, uterine radial artery resistance index (URa-RI) at 8 weeks and uterine artery pulsatility index (Ut-PI) with pre-diastolic notching (Ut-notch) at 11-13 weeks - to better predict successful pregnancies and reduce risks of adverse outcomes.
View Article and Find Full Text PDFWorld J Psychiatry
January 2025
Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, South Korea.
This manuscript explores the recent study by Cui which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor (BDNF) levels in first-episode schizophrenia patients. The study revealed that higher levels of interleukin-6 and tumor necrosis factor-α correlated with reduced BDNF levels and poorer cognitive performance. Schizophrenia is a severe psychiatric disorder impacting approximately 1% of the global population, characterized by positive symptoms (hallucinations and delusions), negative symptoms (diminished motivation and cognitive impairments) and disorganized thoughts and behaviors.
View Article and Find Full Text PDFTher Adv Rare Dis
January 2025
Jinnah Medical and Dental College, Karachi, Pakistan.
Behçet's disease is a kind of variable vessel vasculitis (VVV) and inflammatory systematic disease affecting various organs of the body. The cause of the disease is idiopathic but is most commonly genetic in origin. A positive skin prick test (dermatographia), genital sores, eye irritation, skin sores, and at least three episodes of mouth sores in a year confirm the diagnosis.
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