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Bioassay-guided fractionation of the crude extract of Mitrephora thorelii (Annonaceae) led to the isolation of two clerodane-type diterpenes. Their structures were characterised on the basis of spectroscopic methods as 6alpha,16,18-trihydroxycleroda-3(4),13(14)-dien-15,16-olide (1) and 16-hydroxycleroda-3(4),13(14)-dien-15,16-olide (2). Compound 1 is a new compound. Compounds 1 and 2 exhibited inhibitory activity against the proliferation of human hepatoma BEL-7402 cells in vitro. Compound 2 also showed an in vivo anti-tumour effect against the growth of hepatoma H22 in mice.
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Article Synopsis
- Nine new clerodane-type diterpenoids (caseabalanspenes A-I) were discovered from the twigs and leaves of Casearia velutina, alongside six known compounds.
- The structures of these compounds were identified using spectroscopic techniques and their molecular formulas were confirmed through high-resolution mass spectrometry.
- Among the new compounds, caseabalanspene 3 showed significant anti-inflammasome activity, reducing LDH levels in a dose-dependent manner with an IC value of 2.90 μM.
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