Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Recent studies of resected hippocampus from patients with intractable temporal lobe epilepsy (TLE) have yielded biochemical evidence of signalling pathways associated with apoptosis. The tumor suppressor and transcription factor p53 regulates expression of several genes involved in apoptosis. Cellular levels of p53 are regulated in part by murine double minute 2 (MDM2) via ubiquitination and degradation through the proteasome. Presently, we compared expression of p53 and MDM2 in resected hippocampus from patients with intractable TLE to matched autopsy control samples. Western blotting detected significantly higher levels of p53 within TLE samples than controls. MDM2 levels were significantly lower in patient brain and its cleaved form was more abundant. Immunohistochemistry localized elevated p53 to a mainly nuclear distribution in neurons and glia in sections from TLE hippocampus. These data extend other findings on altered expression of genes regulating cell death and survival decisions in human intractable TLE.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2204088 | PMC |
http://dx.doi.org/10.1016/j.eplepsyres.2007.09.001 | DOI Listing |
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