AI Article Synopsis
- Monoclonal B cell lymphocytosis (MBL) was found in four unaffected family members of a patient with chronic lymphocytic leukaemia (CLL), indicating potential genetic links.
- The unaffected relatives were monitored for five years and exhibited signs of MBL through various advanced testing methods, suggesting a clonal B-cell population.
- This research highlights the importance of studying the immune system's response and its relation to CLL, providing insights into how familial connections might influence lymphoid cancer development.
Article Abstract
Monoclonal B cell lymphocytosis (MBL) was detected in four unaffected first-degree relatives (FDR) in a familial chronic lymphocytic leukaemia (CLL) kindred. The proband remains untreated and two male siblings have died. The four unaffected siblings have been followed for a five-year period. All four FDR developed a kappa(+)CD5(+) MBL detected by flow cytometry. Poymerase chain reaction (PCR) for IGHV rearrangement showed evidence of oligoclonality in three of these individuals. Single cell PCR of flow cytometric sorted kappa(+) cells combined with Ig kappa light chain gene sequencing revealed further evidence of monoclonality in two of these individuals. Three of these individuals all showed evidence of hyper-somatic mutations. The B-cell repertoire in unaffected FDR in familial CLL offers a new area to investigate the interface between the immune system and lymphoid neoplasm.
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| http://dx.doi.org/10.1111/j.1365-2141.2007.06857.x | DOI Listing |
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