Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ndt/gfm633 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
Kidney Blood Press Res
December 2009
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex., USA.
Background/aims: Genetic polymorphisms in the paraoxonase 2 (PON2) gene are thought to alter its activity and contribute to the development of cardiovascular and renal disease risk. The purpose of this study is to determine whether the Arg148Gly, Cys311Ser and rs12794795 polymorphisms of PON2 examined previously by others, are associated with type 2 diabetes (T2DM), and subclinical measures of cardiovascular and renal disease risk in Mexican Americans.
Methods: Study participants (n = 848; 21 families) were genotyped for the three polymorphisms by TaqMan assay.
Alleles and genotypes of polymorphic markers of paraoxonase 1 and paraoxonase 2 genes (PON1 and PON2) encoding enzymes of the body antioxidative defense were compared in type 1 diabetes mellitus patients with or without diabetic nephropathy. The patients with nonoverlapping ("polar") phenotypes constituted different groups. The first group contained patients with diabetic nephropathy (DN+, n = 62), clinical proteinuria (albuminuria above 300 mg per day), and at least 15-year disease duration.
View Article and Find Full Text PDFDRD2 -141C insertion/deletion polymorphism is not associated with schizophrenia: results of a meta-analysis.
Am J Med Genet B Neuropsychiatr Genet
July 2004
Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA..
The gene DRD2, which codes for dopamine receptor D2, has been considered a prime candidate for allelic association testing with schizophrenia based on the strong evidence for involvement of this protein in disease pathophysiology. Recent meta-analyses confirmed a small but reliable association between schizophrenia and the cysteine-coding allele of the Cys311Ser polymorphism of DRD2. In the present study, we sought to determine if another polymorphism (the -141C insertion/deletion) in the same gene, which has been reported to be associated with schizophrenia in several individual studies, would show a similar pattern of association with the disease in a pooled dataset.
View Article and Find Full Text PDFPossible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
Brain Res Mol Brain Res
January 2004
Key Laboratory of Biotherapy of Human Diseases, Department of Medical Genetics, West China Hospital and Division of Human Morbid Genomics, Ministry of Education, Sichuan University, Chengdu, 610041, China.
The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!