Purpose: We examined the safety and potential efficacy of transrectally delivered high intensity focused ultrasound for the full gland ablation of previously untreated localized prostate cancer.
Materials And Methods: A total of 20 patients with localized prostate cancer underwent 1 to 3 high intensity focused ultrasound treatments of the prostate. The primary outcome was safety and the secondary outcomes were prostate specific antigen, prostate biopsy and quality of life measures.
Results: A total of 19 patients had complete followup. Serious adverse events related to treatment were limited with the most common adverse event being transient urinary retention more than 30 days in duration in only 10% of patients. Rectal injury occurred in 1 patient. With 1 to 3 treatments 42% of the patients achieved prostate specific antigen less than 0.5 ng/ml and a negative prostate biopsy.
Conclusions: High intensity focused ultrasound in patients with previously untreated prostate cancer is generally well tolerated and it has the potential to completely ablate the prostate gland. With further refinement of the optimal treatment dose and technique this technology has the potential to be an effective form of therapy for localized prostate cancer.
Background: Employment and relationship are crucial for social integration. However, individuals with major psychiatric disorders often face challenges in these domains.
Aims: We investigated employment and relationship status changes among patients across the affective and psychotic spectrum - in comparison with healthy controls, examining whether diagnostic groups or functional levels influence these transitions.
The School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China; Department of Orthopaedic Surgery, Fuzhou Second Hospital, Fuzhou, Fujian, China.
Background: Hip fracture affects millions of persons and is associated with excess morbidity and mortality. More knowledge is needed to regard the prolonged effects of intensive exercise in relatively frail hip fracture patients. In this meta-analysis, we want to determine whether intensity strength training in patients after hip fracture is superior to general exercises in improving physical function.
Nowadays, factories located in COVID-19 infected countries/regions are facing random outbreaks. If blockchain is adopted, then the outbreaks can be known immediately and emergency production shifting can be enabled, although high crash cost will be incurred. Otherwise, production delay will become inevitable.
Background: Excessive Gestational Weight Gain is a global public health problem with serious and long-term effects on maternal and offspring health. Early identification of at-risk groups and interventions is crucial for controlling weight gain and reducing the prevalence of excessive gestational weight gain. Currently, tools for predicting the risk of excessive gestational weight gain are lacking in China.
Analyzing the distribution characteristics of precipitation pollution intensity in the basin and identifying the main factors affecting the precipitation pollution intensity are the important basis for realizing the accurate management of diffused pollution. Based on the surface water quality data from four typical sections of the main stream of Qinhuai River Basin and rainfall data collected from 2021 to 2022, the distribution characteristics of precipitation pollution intensity in the basin were analyzed, and representative natural and social factors were selected to construct models of the precipitation pollution intensity of ammonia nitrogen （NH-N）, permanganate index, and total phosphorus （TP） based on random forest algorithm. Additionally, the main driving factors of precipitation pollution intensity were identified, and the influencing mechanism was analyzed.
