AI Article Synopsis
- A molecular test using 18 specific signaling proteins in blood plasma can accurately detect Alzheimer's disease and differentiate it from control subjects with nearly 90% accuracy.
- This test is also capable of identifying patients with mild cognitive impairment who are likely to progress to Alzheimer's within a 2-6 year timeframe.
- The analysis suggests that Alzheimer's disease may involve widespread disruptions in blood cell formation, immune responses, cell death, and support for neurons before symptoms appear.
Article Abstract
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
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| http://dx.doi.org/10.1038/nm1653 | DOI Listing |
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