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A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy.
Theranostics
January 2025
Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University 510515, Guangzhou, Guangdong Province, China.
Photodynamic therapy (PDT) has gained widespread attention in cancer treatment, but it still faces clinical problems such as skin phototoxicity. Activatable photosensitizers offer a promising approach to addressing this issue. However, several significant hurdles need to be overcome, including developing effective activation strategies and achieving the optimal balance between photodynamic effects and related side effects.
View Article and Find Full Text PDFThe resistance mechanism of B_P225F and B_H272R mutations in succinate dehydrogenase in Botrytis cinerea.
Int J Biol Macromol
December 2024
State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan 430079, PR China. Electronic address:
Botrytis cinerea populations resistant to succinate dehydrogenase inhibitors (SDHIs) represent a major problem for the sustainable development of modern agriculture. In the present study, the resistance mechanism of B_P225F and B_H272R mutations in B. cinerea SDH (BcSDH) resistant to SDHIs fungicides, including boscalid (BOS), penflufen (PEN), pydiflumetofen (PYD), fluopyram (FLU), and benzovindiflupyr (BEN), was uncovered.
View Article and Find Full Text PDFPhase separation and ageing of glycine-rich protein from tick adhesive.
Nat Chem
November 2024
Laboratory of Physical Chemistry and Soft Matter, Wageningen University and Research, Wageningen, the Netherlands.
Article Synopsis
- - Hard ticks use a protein-rich saliva to attach securely to their hosts, forming a solid cement cone, but the process behind this transformation is not yet understood.
- - This study investigates a glycine-rich protein (GRP) in tick saliva, revealing that it can undergo liquid-liquid phase separation to form sticky biomolecular condensates in salty conditions.
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"Bis-Clamp-Cavity Synergy", an Efficient Approach to Improve Guest Binding Properties of Macrocyclic Host and Its Application on Detection of Al and Arg in Living Cells.
Anal Chem
December 2024
Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education; Key Laboratory of Eco-environmental Polymer Materials of Gansu Province; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Improving the selective and sensitive binding properties of macrocyclic hosts to target guests is always an interesting challenge. Herein, we introduce a novel "bis-clamp-cavity synergy" strategy to enhance the selectivity and binding sensitivity of pillararenes toward target guests. To achieve this goal, we designed and synthesized ,'-bis-hydroxynaphthoylhydrazone-functionalized conjugated pillar[5]arene (), in which bis-hydroxynaphthoylhydrazone plays the role of clamps, while the pillar[5]arene provides the macrocyclic cavity.
View Article and Find Full Text PDF-Sulfonatocalix[4]arene turns peptide aggregates into an efficient cell-penetrating peptide.
RSC Adv
October 2024
Bioprocess Engineering Department, National Institute of Genetic Engineering and Biotechnology (NIGEB) Tehran Iran
A novel cell-penetrating peptide (CPP) called -YR, with as a fluorescent probe, was developed. Initially, we aimed to use Y as a supramolecular host for water-insoluble drugs, with R driving the complex into cells. However, an unexpected hurdle was discovered; the peptide self-assembled into amorphous aggregates, rendering it ineffective for our intended purpose.
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