Melioidosis is an infectious disease caused by gram-negative soil-dwelling bacillus Burkholderia pseudomallei. Musculoskeletal melioidosis mimics other infections both clinically and radiologically. An extensive literature review has been performed over musculoskeletal melioidosis through various search engines such as Pubmed, Embase, Medscape, Altavista and Google. Diagnosis requires a high index of clinical suspicion and is dependent on microbiological confirmation. Prompt treatment with long-term combination antibiotics in high dosages and surgical drainage of abscesses improves survival.
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Musculoskeletal melioidosis-a retrospective review of 22 cases from a tertiary care centre in South Tamilnadu.
Indian J Med Microbiol
December 2024
Department of Microbiology, Velammal Medical College Hospital and research Institute, Madurai, India. Electronic address:
A retrospective review of culture confirmed musculoskeletal melioidosis reported between December 2014 and February 2024 was conducted. 22 of 100 patients with culture proven melioidosis infection had musculoskeletal involvement. Median age was 47 years with 95.
View Article and Find Full Text PDFCardiac and mediastinum involvement in Burkholderia thailandensis infection: A case report and literature review.
Radiol Case Rep
December 2024
Department of Radiology, Faculty of Medicine, Thammasat University Hospital, Pathum Thani, Thailand.
Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is prevalent in Southeast Asia and Northern Australia, presenting various clinical manifestations from asymptomatic to life-threatening infections. Although primarily affecting the lungs, intra-abdominal viscera, and musculoskeletal system, melioidosis can rarely involve the heart and mediastinum, which pose significant diagnostic and therapeutic challenges. Herein, we present the case of a 53-year-old male farmer who presented with persistent fever and chest pain, progressing to pericarditis and cardiac tamponade.
View Article and Find Full Text PDFEpidemiology and clinical spectrum of melioidosis: Analysis of cases from a tertiary care centre in southern Tamil Nadu.
Natl Med J India
August 2024
Department of Microbiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad 508126, Telengana, India.
Background We studied the clinical features and treatment outcome of patients with melioidosis in our hospital. Methods We did this retrospective observational chart review over a period of 7 years between December 2014 and February 2022. Results There were 59 cases and 23 deaths attributable to melioidosis over the study period.
View Article and Find Full Text PDFIntroduction: Burkholderia infection commonly presents as bacteraemic pulmonary disease; however, it is notorious for its wide variety of presentations in chronic cases, including musculoskeletal manifestations. It is common in patients living in endemic areas with comorbidities such as diabetes and who have chronic alcoholism. It was previously under-reported due to a low index of suspicion.
View Article and Find Full Text PDFOral Melioidosis in Odontogenic Keratocyst of Mandible.
J Maxillofac Oral Surg
July 2022
Department of Microbiology, All India Institute of Medical Sciences (AIIMS), Raipur, India.
Melioidosis is a potentially fatal, life-threatening infection caused by the gram-negative saprophytic organism Burkholderia. It is a disease endemic to Southeast Asia and Northern Australia. This infection transmits through direct contact, cutaneous inoculation, inhalation, or ingestion, and patients clinically exhibit abscesses in single or multiple organs.
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