This paper provides an overview of the use of matrix models within the context of Pharmacotherapy. It also discusses the application of these matrix models to the Safe Therapeutic Economic Pharmaceutical Selection (STEPS) approach used in Northern Ireland.
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http://dx.doi.org/10.1517/14656566.8.s1.s65 | DOI Listing |
Environ Geochem Health
January 2025
Shandong Bureau of China Metallurgical Geology Bureau, Qingdao, 266109, China.
The natural environment and public health are gravely threatened by the enrichment of soil potentially toxic elements (PTEs). To explore the contamination level, sources and human health risks posed by PTEs, high-density soil sampling was carried out in the upper Wei River region (UWRR). The results demonstrated that the pollution risk and ecological risk in UWRR as a whole were at a low level, but there were moderate or higher ecological risks of Hg and Cd in some areas.
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January 2025
Inserm, Gustave Roussy, Centre for Research in Epidemiology and Population Health (CESP), "Exposome, Heredity, Cancer, and Health" Team, Université Paris-Saclay, UVSQ, 12 Avenue Paul Vaillant Couturier, 94805, Villejuif, France.
Persistent organic pollutants (POPs) are a group of organic chemical compounds. Contradictory results have emerged in epidemiological studies attempting to elucidate their relationship with breast cancer risk. This study explored the relationship between dietary exposures to multiple POPs and ER-positive breast cancer risk in the French E3N cohort study, using three different approaches to handle multicollinearity among exposures.
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January 2025
Department of Microbiology and Immunology, Brain Korea 21 Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.
Blood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear. Here, we investigate the role of NLRP3 inflammasome in BBB disruption following peripheral inflammatory challenges. Repeated intraperitoneal lipopolysaccharide administration causes NLRP3-dependent BBB permeabilization and myeloid cell infiltration into the brain.
View Article and Find Full Text PDFEcology
January 2025
Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Oslo, Norway.
Many vector-borne diseases are sensitive to changes in land use and climate; hence, it is important to understand the factors that govern the vector populations. Ixodid ticks, which serve as vectors for multiple diseases, have a slow life cycle compared with many of their hosts. The observable questing population represents only a fraction of the total tick population and may include overlapping cohorts in each stage.
View Article and Find Full Text PDFAm Surg
January 2025
Department of Surgery and Trauma, Broward Health Medical Center, Ft. Lauderdale, FL, USA.
Introduction: American College of Surgeons-Committee on Trauma (ACS-COT) defines minimum Standard Criteria (SC) for Level 1 trauma. In our hospital, discretion of prehospital personnel ("Paramedic Judgment" [PJ]) can initiate Full Trauma Triage Activation (FTTA) in the absence of ACS-COT criteria. The aim of this study was to evaluate overtriage and undertriage for PJ vs SC.
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