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| http://dx.doi.org/10.1002/clc.20148 | DOI Listing |
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Alzheimers Dement
December 2024
University of Washington, Seattle, WA, USA.
Background: The SORL1 gene (SORLA) is strongly associated with risk of developing Alzheimer's disease (AD). SORLA is a regulator of endosomal trafficking in neurons and interacts with retromer, a complex that is a "master conductor" of endosomal trafficking. Because of its size, SORLA is difficult to target therapeutically.
View Article and Find Full Text PDFImportance: Classification of persons with long COVID (LC) or post-COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves.
Objective: To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities.
Background: Many hospitals and surgery centers have focused improvement efforts on operating room inefficiencies. A common inefficiency is missing and unusable surgical instrumentation, which can result in case delays and decreased effectiveness. Lean Six Sigma methodology, a set of process improvement tools focused on the reduction of waste and variation, has been used to identify and correct root causes of missing and unusable instrumentation.
View Article and Find Full Text PDFProton Sensing GPCR's: The missing link to Warburg's Oncogenic Legacy?
J Cancer Biol
January 2024
Department of Medicine, Michigan State University College of Human Medicine, East Lansing, MI, USA.
Article Synopsis
- - The Warburg effect describes how cancer cells favor aerobic glycolysis, producing more lactate even with oxygen available, which leads to an acidic tumor environment that promotes cancer traits like drug resistance and immune evasion.
- - Proton-sensing G-protein-coupled receptors (GPCRs), such as GPR68, can detect this acidity and activate cancer-promoting signaling pathways, suggesting a link between the acidic environment and tumor growth mechanisms.
- - Understanding how these proton-sensing receptors relate to the Warburg effect could open up new avenues for cancer treatment by targeting the metabolic changes that favor tumor development.
Case Report: Alpha6 Integrin Disorder Presenting in Childhood with Nail Dysplasia and Onycholysis But No History of Fragile or Bullous Skin Changes.
Glob Med Genet
December 2024
Division of Genetics and Metabolism, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, United States.
We report a 7-year-old girl born with pyloric atresia but without congenital epidermolysis bullosa or skin fragility. Nail dysplasia developed at age 8 months and throughout childhood she suffered from onycholysis and mild nail hypertrophy. Whole-exome sequencing demonstrated biallelic mutations in alpha6 integrin (ITGA6): p.
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