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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment.
Pharmaceutics
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, Iran.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body's organs, tissues, and cells that can be selectively transported to specific regions.
View Article and Find Full Text PDFAll-sky 1 km land surface temperature (LST) data are urgently needed. Two widely applied approaches to derive such LST data are merging thermal infrared remote sensing (TIR)-passive microwave remote sensing (PMW) observations and merging TIR reanalysis data. However, as only the Moderate Resolution Imaging Spectroradiometer (MODIS) is adopted as the TIR source for merging, current 1 km all-sky LST products are limited to the MODIS observation time.
View Article and Find Full Text PDFPassive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach.
Sensors (Basel)
January 2025
School of Computer Science, University of Birmingham, Birmingham B15 2TT, UK.
Objective and continuous monitoring of Parkinson's disease (PD) tremor in free-living conditions could benefit both individual patient care and clinical trials, by overcoming the snapshot nature of clinical assessments. To enable robust detection of tremor in the context of limited amounts of labeled training data, we propose to use prototypical networks, which can embed domain expertise about the heterogeneous tremor and non-tremor sub-classes. We evaluated our approach using data from the Parkinson@Home Validation study, including 8 PD patients with tremor, 16 PD patients without tremor, and 24 age-matched controls.
View Article and Find Full Text PDFand Extracts Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway.
Int J Mol Sci
January 2025
Department of Health Sciences and Technology, Gachon Advanced Institute for Health Science & Technology, Gachon University, Incheon 21999, Republic of Korea.
Ischemic stroke, caused by blocked cerebral blood flow, requires prompt intervention to prevent severe motor and cognitive impairments. Despite extensive drug development efforts, the failure rate of clinical trials remains high, highlighting the need for novel therapeutic approaches. This study investigated the therapeutic potential of a natural herbal extract mixture of Bunge (AM) and Georgi (SB), traditionally used in Eastern Asian herbal medicine (EAHM) for ischemic stroke treatment.
View Article and Find Full Text PDFDesign and Investigation of a Passive-Type Microfluidics Micromixer Integrated with an Archimedes Screw for Enhanced Mixing Performance.
Micromachines (Basel)
January 2025
Faculty of Mechanical Engineering and Design, Kaunas University of Technology, 51424 Kaunas, Lithuania.
In recent years, microfluidics has emerged as an interdisciplinary field, receiving significant attention across various biomedical applications. Achieving a noticeable mixing of biofluids and biochemicals at laminar flow conditions is essential in numerous microfluidics systems. In this research work, a new kind of micromixer design integrated with an Archimedes screw is designed and investigated using numerical simulation and experimental approaches.
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