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PhiSiCal-Checkup: A Bayesian framework to validate amino acid conformations within experimental protein structures.
Proc Natl Acad Sci U S A
January 2025
Department of Data Science and Artificial Intelligence, Monash University, Clayton, VIC 3800, Australia.
As structural biology and drug discovery depend on high-quality protein structures, assessment tools are essential. We describe a new method for validating amino-acid conformations: "PhiSiCal ([Formula: see text]al) Checkup." Twenty new joint probability distributions in the form of statistical mixture models explain the empirical distributions of dihedral angles [Formula: see text] of canonical amino acids in experimental protein structures.
View Article and Find Full Text PDFPhysical violence and its associations: Insights from nationally representative data in India.
Womens Health (Lond)
January 2025
Global Health, and Department Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Article Synopsis
- Empowerment is crucial for women in India, yet patriarchal norms limit their autonomy, leading to heightened domestic violence and health issues.
- The study aims to explore how different dimensions of women's empowerment relate to their attitudes toward justifying physical violence in certain situations, suggesting that increased empowerment may reduce acceptance of such violence.
- Data was analyzed from the National Family Health Survey-5 (2019-2021), revealing low employment rates among women, high asset ownership, and significant instances of justified physical violence, indicating a complex relationship between empowerment and domestic abuse.
Template-Guided Nondeterministic Assembly of Organosilica Nanodots for Multifunctional Physical Unclonable Functions.
ACS Appl Mater Interfaces
January 2025
Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Jieyang 515200, China.
Optical physical unclonable functions (PUFs) are gaining attention as a robust security solution for identification in the expanding Internet of Things (IoT). To enhance the security and functionality of PUFs, integrating multiple optical responses─such as fluorescence and structural color─into a single system is essential. These diverse optical properties enable multilevel authentication, where different layers of security can be verified under varying light conditions, greatly reducing the risk of counterfeiting.
View Article and Find Full Text PDFRecovery From Heroin Addiction: A Qualitative Study.
Public Health Nurs
December 2024
College of Nursing, Kent State University, Kent, Ohio, USA.
Objective: Understanding the recovery process from heroin addiction is crucial as nonmedical opioid use persists. This study aims to comprehensively describe the recovery journey, focusing on the experiences and challenges faced by individuals in recovery to inform treatment approaches and support strategies.
Methods: This qualitative study, guided by critical social theory, emphasized balancing power dynamics and fostering equal participation to ensure all voices are heard, challenging traditional hierarchies and promoting inclusivity.
Assuring assistance to healthcare and medicine: Internet of Things, Artificial Intelligence, and Artificial Intelligence of Things.
Front Artif Intell
December 2024
Hospital and Rehabilitation Centre for the Disabled Children (HRDC), Banepa, Nepal.
Introduction: The convergence of healthcare with the Internet of Things (IoT) and Artificial Intelligence (AI) is reshaping medical practice with promising enhanced data-driven insights, automated decision-making, and remote patient monitoring. It has the transformative potential of these technologies to revolutionize diagnosis, treatment, and patient care.
Purpose: This study aims to explore the integration of IoT and AI in healthcare, outlining their applications, benefits, challenges, and potential risks.
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