Recently, the use of non-steroidal anti-inflammatory drug(NSAID) as an anti-inflammatory analgesic and antithrombotic has increased with the general aging of our society. Although it is understood that gastric mucosal injury is most-frequent side-effect of NSAID, there are actually a variety of mechanisms that NSAID has, some which are due to the depressed production of prostaglandin (PG). The main action of PG in the gastric mucosa is the regulation of gastric mucosa protecting mechanism and if PG is insufficient, the gastric mucosa is weakened. As endogenous PG decreases, there is a decrease in mucus production accompanied by a decrease in bicarbonate secretion, problems with, an increase of stomach motility, tissue restoration suppression and so on. As a result, it is considered that the defense mechanisms decrease and gastric mucosal injury occurs.
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