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Comparative analysis of mortality patterns and treatment strategies in thalassaemia and sickle cell disease patients: A 12-year study.
Br J Haematol
March 2025
Thalassemia and Sickle Cell Disease Unit, Department of Hematology, General Hospital of Larissa, Larissa, Greece.
This study examined mortality rates among 2475 patients with thalassaemia and sickle cell disease (SCD) per year over 12 years in Greece, recording 335 deaths (27.92/year), with an overall mortality rate of 1.13% per year.
View Article and Find Full Text PDFSurgery of the Primary Tumor in de novo Metastatic Breast Cancer: A Palliative Approach or a Potential Survival Game-Changer?
Ann Ital Chir
March 2025
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Approximately 5-10% of primary breast cancer cases present as de novo stage IV disease, characterized by distant metastases at diagnosis. Traditionally, systemic therapies such as chemotherapy, endocrine therapy and targeted treatments have formed the cornerstone of treatment for metastatic breast cancer (MBC), focusing on disease control, symptom palliation and quality of life improvement. While systemic therapies remain crucial, the role of local treatments, particularly surgery for the primary tumor, is increasingly debated.
View Article and Find Full Text PDFObesity substantially impacts rheumatic and musculoskeletal diseases: time to act.
Ann Rheum Dis
March 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Obesity is a major health problem and risk factor for many chronic health conditions, including rheumatic and musculoskeletal diseases (RMDs). Around 7 in 10 adults with RMD live overweight or with obesity. Obesity not only increases the risk of developing RMDs.
View Article and Find Full Text PDFBrain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction.
J Prev Alzheimers Dis
March 2025
Department of Neurosciences, University of California, San Diego, California, USA; Alzheimer's Disease Cooperative Study, School of Medicine, University of California. San Diego California USA.
Background: Online educational programs focused on ways to improve brain health could increase participant literacy, empowerment, and engagement in activities that support personal brain health, potentially reducing dementia risk.
Objectives: Our goal was to develop an evidence-based online educational program with a focus on risk and protective factors for dementia. Here we present the rationale and features of the program and include results from a pilot study that assessed usability and acceptability.
Feasibility and impact of an expanded upper extremity musculoskeletal health for musicians (MHM) program on arm and hand pain in musicians.
J Hand Ther
March 2025
Leon Root, MD Motion Analysis Laboratory, Department of Rehabilitation, Hospital for Special Surgery, New York, NY, USA. Electronic address:
Background: This easibility cohort study follows a prior randomized control pilot trial that examined the feasibility and impact of a formal Musculoskeletal Health for Musicians (MHM) program. In this follow-up study, an expanded program was designed to target hand and arm pain by adding exercises for the wrist, elbow, forearm, and hand intrinsic muscles. The MHM program combines education with exercise instruction to prevent pain and injury in musicians.
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