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International normalized ratio measurement during perioperative anticoagulation bridging with low-molecular-weight heparin in patients undergoing heart valve replacement surgery.
Res Pract Thromb Haemost
November 2024
Laboratory of Hematology, Department of Laboratory Medicine, Radboud UMC, Nijmegen, the Netherlands.
Background: Surgical procedures in anticoagulated patients require specific attention due to increased bleeding risk. Preoperative anticoagulation interruption in high-risk patients is often necessary. Bridging anticoagulation with low-molecular-weight heparin (LMWH) minimizes thromboembolic risk, but its effect on international normalized ratio (INR) measurement is not well established, necessitating careful monitoring and individual assessment.
View Article and Find Full Text PDFInterference of lupus anticoagulant causing antiprothrombin and anti-beta-2-glycoprotein I antibodies on international normalized ratio measurements: comparative analysis of international normalized ratio methods.
Res Pract Thromb Haemost
July 2024
Department of Clinical Chemistry, Meander Medical Centre, Amersfoort, the Netherlands.
Background: Life-long vitamin K antagonist (VKA) therapy is recommended as a standard of care in antiphospholipid syndrome (APS) patients with thrombosis. Concerns have been raised about the validity of international normalized ratio (INR) measurements in lupus anticoagulant (LA)-positive APS patients because LA may interfere with phospholipid-dependent coagulation tests and could elevate INR measurements.
Objectives: Here, we aimed to determine the interference of antigen-specific monoclonal and isolated patient antibodies with LA activity on INR measurements.
CoaguChek and Coag-Sense PT2 Meter Point of Care INR Device Validation.
Mayo Clin Proc
July 2024
Department of Laboratory Medicine, Mayo Clinic, Rochester, MN, USA.
Objective: To standardize international normalized ratio (INR) measurements and improve data integrity by enabling electronic result transmission for warfarin monitoring, two point-of-care (POC) devices were evaluated against an internal plasma INR reference method.
Methods: A multicenter study was pursued (January 24, 2022, through October 19, 2022) to compare concordance of two commercially available POC devices, Coag-Sense PT2 Meter (Coag-Sense) and CoaguChek XS Pro and Plus devices (CoaguChek), against an internal plasma INR method among patients treated with warfarin. Bias and linear regression analysis were assessed for these devices including dosing decision accuracy compared with plasma INR reference.
Reliability of International Normalized Ratio Results in the CoaguChek Pro II System in a Clinical Setting.
Clin Appl Thromb Hemost
November 2023
Department of Hematology, National Institute of Cardiology Ignacio Chávez, México City, México.
The National Institute of Cardiology has previously used the CoaguChek XS Plus system (Roche Diagnostics International Ltd), comparing capillary blood prothrombin time/international normalized ratio (PT/INR) results with those obtained using BCS-XP/Thromborel (Siemens). We assessed the reliability of PT/INR results using the third-generation CoaguChek Pro II system, the CoaguChek XS Plus system, and cobas t 411 for citrated plasma analysis. Venous and capillary PT/INR were measured (N = 204).
View Article and Find Full Text PDFEvaluating the Effect of Timing on Point-of-Care Testing of INR.
J Pharm Pract
June 2024
Diasyst, Atlanta, GA, USA.
To evaluate if there is a difference in International Normalized Ratio (INR) readings taken within the 15 second time frame after lancing the finger vs 30-60 seconds of obtaining a blood drop utilizing a CoaguChek XS Plus point-of-care (POC) INR machine in patients on warfarin therapy. All adult patients on anticoagulation therapy with warfarin who were managed in a pharmacist-run anticoagulation clinic were considered for inclusion in the study. The mean difference of INR readings taken less than 15 seconds vs between 30-60 seconds after the blood drop was obtained from the finger was assessed.
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