Our purpose was to compare admissions criteria as predictors of dental school performance in underachieving and normally tracking dental students. Underachieving dental students were identified by selecting ten students with the lowest class grade point average following the first year of dental school from five classes, resulting in a pool of fifty students. Normally tracking students served as a control and were randomly selected from students who had completed their first year of dental school not in the underachieving group. Admission measures of college grade point average (GPA), science grade point average (SGPA), academic average (AA), Perceptual Ability Test (PAT), college rigor, and academic load in college were evaluated with descriptive statistics, correlation, and regression analysis with first-year and graduating GPA as the dependent variables. Admissions criteria were generally weak predictors of first-year and graduating GPA. However, first-year dental school GPA was a strong predictor (R(2)=0.77) of graduating GPA for normally tracking students and a moderate predictor (R(2)=0.58) for underachieving students. Students who completed the first year of dental school having a low GPA tended to graduate with a low GPA. Therefore, remediation and monitoring would be important during the dental school experience for these students.
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J Clin Invest
January 2025
Center for Inherited Myology Research, Virginia Commonwealth University, Richmond, United States of America.
Background: Myotonic dystrophy type 1 (DM1) is a multisystemic, CTG repeat expansion disorder characterized by a slow, progressive decline in skeletal muscle function. A biomarker correlating RNA mis-splicing, the core pathogenic disease mechanism, and muscle performance is crucial for assessing response to disease-modifying interventions. We evaluated the Myotonic Dystrophy Splice Index (SI), a composite RNA splicing biomarker incorporating 22 disease-specific events, as a potential biomarker of DM1 muscle weakness.
View Article and Find Full Text PDFOral Radiol
January 2025
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Av. Limeira, 901, Areião, Piracicaba, SP, 13414-903, Brazil.
Objectives: To assess the influence of a handheld X-ray unit in the diagnosis of proximal caries lesions using different digital systems by comparing with a wall-mounted unit.
Methods: Radiographs of 40 human teeth were acquired using the Eagle X-ray handheld unit (Alliage, São Paulo, Brazil) set at 2.5 mA, 60 kVp and an exposure time of 0.
Exp Aging Res
January 2025
Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Objective: Cognitive dysfunction is a significant issue in old age and can cause many problems in older adults, especially those with diabetes. This study aimed to investigate the association between oral health status and DMFT index with cognitive dysfunction in community-dwelling older adults with T2D (type 2 diabetes).
Methods: This was a cross-sectional study that included 245 older people aged 60 years and older with T2D, visiting healthcare centers in north of Iran, using the cluster sampling method.
J Clin Hypertens (Greenwich)
January 2025
SR Sanjeevani Hospital, Siraha, Kalyanpur, Nepal.
Sex hormone-binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta-analysis explores the potential of SHBG as a biomarker for predicting GH and PE.
View Article and Find Full Text PDFCytoskeleton (Hoboken)
January 2025
Department of Life Science, Faculty of Science, Gakushuin University, Mejiro, Tokyo, Japan.
Cytokinesis in animal and fungal cells requires the contraction of actomyosin-based contractile rings formed in the division cortex of the cell during late mitosis. However, the detailed mechanism remains incompletely understood. Here, we aim to develop a novel cell-free system by encapsulating cell extracts obtained from fission yeast cells within lipid vesicles, which subsequently leads to the formation of a contractile ring-like structure inside the vesicles.
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