Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.
Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.
Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers.
Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.
Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.
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| http://dx.doi.org/10.1001/archneur.64.10.1482 | DOI Listing |
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