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Dendritic cells under the control of the preimplantation embryo secretome: an in vitro study.
Reprod Biol Endocrinol
November 2024
Department of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Anichstraße 35, Innsbruck, 6020, Austria.
Objective: To study the crosstalk between maternal immune cells and the developing embryo by investigating the immunogenic properties of human blastocyst spent media (SM) on dendritic cells.
Methods: In this prospective multicenter experimental study, human preimplantation embryo spent media were collected after blastocyst formation, grouped based on successful or unsuccessful implantation, and analyzed by protein array or used to stimulate monocyte derived dendritic cells (moDC). The immunomodulatory properties of SM on moDC were investigated by analyzing changes in phenotype, cytokine secretion, indoleamine 2,3-dioxygenase (IDO) activity, and ability to activate T cells.
Spatiotemporal dynamics and selectivity of mRNA translation during mouse pre-implantation development.
bioRxiv
October 2024
Department of Animal Sciences, Genetics Institute, University of Florida, Gainesville, FL 32610, USA.
Translational regulation is pivotal during preimplantation development. However, how mRNAs are selected for temporal regulation and their dynamic utilization and fate during this period are still unknown. Using a high-resolution ribosome profiling approach, we analyzed the transcriptome, as well as monosome- and polysome-bound RNAs of mouse oocytes and embryos, defining an unprecedented extent of spatiotemporal translational landscapes during this rapid developmental phase.
View Article and Find Full Text PDFThe frontier of precision medicine: application of single-cell multi-omics in preimplantation genetic diagnosis.
Brief Funct Genomics
December 2024
Reproductive Medical Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China.
The advent of single-cell multi-omics technologies has revolutionized the landscape of preimplantation genetic diagnosis (PGD), offering unprecedented insights into the genetic, transcriptomic, and proteomic profiles of individual cells in early-stage embryos. This breakthrough holds the promise of enhancing the accuracy, efficiency, and scope of PGD, thereby significantly improving outcomes in assisted reproductive technologies (ARTs) and genetic disease prevention. This review provides a comprehensive overview of the importance of PGD in the context of precision medicine and elucidates how single-cell multi-omics technologies have transformed this field.
View Article and Find Full Text PDFProtein Modifications During Early Embryo Development.
Am J Reprod Immunol
October 2024
Center for Reproductive Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Background: Infertility is a global reproductive health burden. Assisted reproductive technologies (ARTs) have been widely used to help patients become pregnant. Few embryos develop to the blastocyst stage with ARTs, leading to relatively low live birth rates.
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