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Recalibrating Perceptions and Attitudes Toward Nebulizers versus Inhalers for Maintenance Therapy in COPD: Past as Prologue.
Int J Chron Obstruct Pulmon Dis
December 2024
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Aerosol therapy administered via handheld inhaler or nebulizer device has long been standard for the treatment of chronic obstructive pulmonary disease (COPD), both for maintenance therapy and for management of acute exacerbations. Of the 2 options for drug delivery, inhaler devices are the most widely used for ambulatory patients with COPD as they are small, portable, and convenient and offer an array of medication options. They are, however, prone to suboptimal inhalation technique and use errors, which decrease the amount of medication delivered, compromise efficacy, and adversely affect clinical outcomes.
View Article and Find Full Text PDFPrologue: Leading women in respiratory clinical sciences.
Respirology
December 2024
College of Nursing, Medical University of South Carolina, Charleston, South Carolina, USA.
Special Series: Leading Women in Respiratory Clinical Sciences Series Editors: Anne-Marie Russell and Kathleen O Lindell See related Letter.
View Article and Find Full Text PDFThe history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras.
MAbs
July 2024
Process & Product Development, Vir Biotechnology Inc, San Francisco, CA, USA.
Therapeutic monoclonal antibody (mAb) development and the processes for manufacturing drug substance have evolved since the first approval of the mAb in 1986. As the past is often the prologue to the future, the history of these technologies has been classified here into three eras, leading to speculation about what the next era may hold with regard to development and manufacturing strategies, as well as the potential impacts to patients. The substantial increase in production culture titers and bioreactor production volumes and the availability of large-scale contract manufacturing facilities could translate into improved global access for these therapies and an expansion of indications for therapeutic antibodies.
View Article and Find Full Text PDFAstrocytic Na, K ATPases in physiology and pathophysiology.
Cell Calcium
March 2024
Section of Neuroscience and Cell Biology, Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy; Center for Neurobiology of Aging, IRCCS INRCA, Ancona, Italy. Electronic address:
The Na, K ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na, K ATPases, the review focuses on the role of the astrocytic Na, K pumps in extracellular K and glutamate homeostasis, intracellular Na and Ca homeostasis and signaling, regulation of synaptic transmission and neurometabolic coupling between astrocytes and neurons. Loss-of-function mutations in the gene encoding the astrocytic α2 Na, K ATPase cause a rare monogenic form of migraine with aura (familial hemiplegic migraine type 2).
View Article and Find Full Text PDFFrontiers of Cranial Base Surgery: Integrating Technique, Technology, and Teamwork for the Future of Neurosurgery.
Brain Sci
October 2023
Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
The landscape of cranial base surgery has undergone monumental transformations over the past several decades. This article serves as a comprehensive survey, detailing both the historical and current techniques and technologies that have propelled this field into an era of unprecedented capabilities and sophistication. In the prologue, we traverse the historical evolution from rudimentary interventions to the state-of-the-art neurosurgical methodologies that define today's practice.
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