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Late-Onset Idiopathic Generalized Epilepsy Manifesting With De Novo Late-Onset Absence Status Epilepticus After COVID-19 Infection: A Case Report.
Cureus
November 2024
Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN.
Herein, we present a case of idiopathic generalized epilepsy (IGE) manifesting as de novo late-onset absence status epilepticus (ASE) following mild coronavirus disease 2019 (COVID-19). A woman in her 40s presented with persistent 3-5.5 Hz generalized spike-wave complexes (SWCs) on electroencephalography (EEG).
View Article and Find Full Text PDFTrends in antiseizure medication prescription in Idiopathic generalized epilepsy over the last 10 years.
Epilepsy Behav
November 2024
Epilepsy Unit, Neurology Department, Medicine Department, Universitat Autònoma de Barcelona. Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, 08035, Barcelona, Spain; Research group on Status Epilepticus and Acute Seizures, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Hospital Campus, 08035, Barcelona, Spain.
Background: Idiopathic Generalized Epilepsies (IGE) are a subset of syndromes defined by the International League against Epilepsy (ILAE) with the particularity to respond to a narrow number of ASMs and particularly to valproic acid (VPA). Recommendations have changed in the last decade. We aimed to describe changes in antiseizure medication (ASM) in adult IGE over the last 10 years.
View Article and Find Full Text PDFPirfenidone-induced liver injury, a case report of a rare idiosyncratic reaction.
Ther Adv Drug Saf
September 2024
Service d'Hépato-gastroentérologie, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium.
Article Synopsis
- Nearly all medications can cause drug-induced liver injury (DILI), which often has unpredictable and poorly understood reactions.
- Pirfenidone, an antifibrotic drug for idiopathic pulmonary fibrosis, can elevate liver enzymes but usually doesn't require stopping the medication.
- This case study discusses a 70-year-old woman who experienced acute hepatocellular hepatitis due to pirfenidone, emphasizing the importance of early detection and reporting of DILI.
An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol.
PLoS One
August 2024
Institute of Systems, Molecular and Integrative Biology, Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men's offspring, prompting recommendations to restrict use in everybody aged <55 years.
View Article and Find Full Text PDFLamotrigine vs levetiracetam in female patients of childbearing age with juvenile absence epilepsy: A Bayesian reanalysis.
Epilepsia
October 2024
Department of Human Neurosciences, Sapienza University, Rome, Italy.
Article Synopsis
- * A multicenter study reanalyzed the effectiveness of LEV vs. LTG, revealing that LTG had significantly lower treatment failure rates and better medication retention than LEV.
- * Both medications had similar safety profiles, and while there were no notable differences in achieving total seizure freedom, LTG showed a strong likelihood of being superior for overall treatment effectiveness.
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