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Experience, Outcomes, and Insights on Endoscopic Colonic Polyp Excision: A Retrospective Cohort Study.
Cureus
December 2024
General Surgery, Maidstone and Tunbridge Wells NHS Trust, Maidstone, GBR.
Introduction Colorectal cancer (CRC) continues to pose a major public health challenge, ranking among the most common malignancies globally and being a leading cause of cancer-related mortality. Most CRCs originate from adenomatous polyps, underscoring the importance of detecting and removing these precancerous growths as a key preventive measure against CRC. In particular, large colonic polyps (≥10 mm) warrant special attention due to their increased risk of progressing to malignancy compared to smaller polyps.
View Article and Find Full Text PDFIntegrative analysis of Ewing's sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy.
Cell Commun Signal
January 2025
Department of Musculoskeletal Tumor, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Background: Ewing's sarcoma (EwS), a common pediatric bone cancer, is associated with poor survival due to a lack of therapeutic targets for immunotherapy or targeted therapy. Therefore, more effective treatment options are urgently needed.
Methods: Since novel immunotherapies may address this need, we performed an integrative analysis involving single-cell RNA sequencing, cell function experiments, and humanized models to dissect the immunoregulatory interactions in EwS and identify strategies for optimizing immunotherapeutic efficacy.
Serological Detection of Ovine Gammaherpesvirus 2 Antibodies in Dairy Farms from Southern Brazil.
Microorganisms
December 2024
Moredun Research Institute, Pentlands Science Park, Midlothian, Edinburgh EH26 0PZ, UK.
Article Synopsis
- SA-MCF is a serious disease in cattle caused by OvGHV2, with a global presence and potential reservoirs in wild boars.
- Previous detection methods for MCF used a CI-ELISA based on a specific antigen, but this study tested a new indirect ELISA specific to OvGHV2 antibodies in dairy cattle from Southern Brazil.
- The results showed that nearly 38% of farms had at least one seropositive cow, with intensified farming systems showing a significantly higher risk for seropositivity, suggesting a link between environmental factors and disease prevalence.
Breast Adenocarcinoma and Cold Agglutinin Disease: A Paraneoplastic Syndrome.
Cureus
November 2024
Department of Oncology, Medical University of South Carolina, Charleston, USA.
Autoimmune hemolytic anemia is a disorder that is characterized by the destruction of red blood cells through an autoimmune process, such as temperature-dependent antibodies. The two predominant types, cold agglutinin and warm agglutinin disease, typically possess different underlying etiologies. Prompt recognition and workup of autoimmune hemolytic anemia should be prioritized to potentially uncover any underlying primary cause, such as malignancy.
View Article and Find Full Text PDFEffects of intermittent hand-foot hypothermia therapy on chemotherapy-induced peripheral neurotoxicity.
Support Care Cancer
December 2024
Tangshan People's Hospital, Tangshan, 063000, China.
Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in patients with breast cancer undergoing chemotherapy. This study aimed to assess the effects of three different intermittent hypothermia temperatures applied to the hands and feet on CIPN symptoms in patients with breast cancer undergoing chemotherapy.
Methods: In total, 108 patients were randomly divided into three experimental groups (n = 36).
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