AI Article Synopsis

  • A study suggests that higher intake of soy isoflavones may improve blood vessel function and reduce atherosclerosis in people at high risk for cardiovascular diseases.
  • Researchers examined the dietary habits of 126 patients (mostly males around 66 years old) with existing cardiovascular issues.
  • Results showed that those consuming the most isoflavones experienced significantly better blood flow response and reduced artery thickness compared to those with lower intakes.

Article Abstract

Background: Epidemiologic studies have suggested that a high phytoestrogen intake is inversely associated with cardiovascular disease risk factors and the incidence of cardiovascular events. However, the relation between the intake of isoflavone, a major component of phytoestrogen, and vascular endothelial function and the atherosclerotic burden remains unclear.

Objective: We aimed to investigate the effects of various dietary soy isoflavone intakes on brachial artery flow-mediated dilation and mean maximum carotid intima-media thickness.

Design: We studied 126 consecutive patients (x +/- SD age: 66.5 +/- 11.1 y; 69% male) at high risk of cardiovascular events (94% had documented coronary artery disease or stroke; 44% had diabetes). A validated food-frequency questionnaire was used to estimate their dietary intake after they achieved stable dietary patterns for 3 mo.

Results: The median intakes of isoflavone and soy protein were 5.5 (range: 2.2-13.3) mg/d and 1.2 (range: 0.4-2.8) g/d, respectively. Persons in the 4th quartile of daily isoflavone intake had significantly (P < 0.05) greater flow-mediated dilation-but not mean maximum carotid intima-media thickness-than did those in the lower quartiles. After adjustment for potential confounders, a higher isoflavone intake in the 4th than in the 1st quartile (>13.3 mg/d), but not a higher intake of soy protein, predicted an absolute 2.71% increase in flow-mediated dilation (relative increase: 103%; P = 0.02) and a 0.17-mm decrease in mean maximum carotid intima-media thickness (relative decrease: 14.5%; P = 0.04).

Conclusion: In persons at high risk of cardiovascular events, a greater isoflavone intake is associated with better vascular endothelial function and lower carotid atherosclerotic burden.

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcn/86.4.938DOI Listing

Publication Analysis

Top Keywords

isoflavone intake
16
cardiovascular events
16
high risk
12
risk cardiovascular
12
vascular endothelial
12
endothelial function
12
atherosclerotic burden
12
maximum carotid
12
carotid intima-media
12
persons high
8

Similar Publications

Background: Dietary adjustment has consistently been regarded as an effective and health way for both the prevention and treatment of constipation. Several researches suggest a significant correlation between dietary flavonoids intake and gut microbiota, while the relationship between dietary flavonoids and constipation has not been reported. The objective of this study is to investigate the relationship between flavonoids intake and constipation.

View Article and Find Full Text PDF

Background: Although phytoestrogens modulated pancreatic tumour growth in experimental studies, it remains unclear whether phytoestrogen intake is associated with pancreatic cancer.

Methods: Of 92,278 persons who completed the Diet History Questionnaire in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, 346 were diagnosed with pancreatic cancer within a median follow-up of 9.4 years.

View Article and Find Full Text PDF

Beige adipocytes arise from white adipocytes in response to cold or other stimuli, known as browning of white adipose. Beige adipocytes play a role similar to that of brown adipocytes, express high levels of uncoupling protein 1 (UCP1), and are responsible for energy consumption via heat production, thus aiding in fat loss. Although histidine (His) and soy isoflavone (Iso) co-ingestion reportedly reduces food intake, body weight, and fat accumulation in female rats, the underlying mechanism remains unclear.

View Article and Find Full Text PDF

Estrogen has demonstrated beneficial effects; however, it can also have unfavorable effects. Phytoestrogens are present in many consumable products and commonly used as supplements. These are of interest as they may have beneficial effects on mood with fewer undesirable effects on reproductive tissues.

View Article and Find Full Text PDF
Article Synopsis
  • Genistin, an isoflavone found in soybeans, was tested on 72 gestating sows to see how it affects reproductive performance and immunity by supplementing their diet with 150 mg/kg.
  • Results indicated that genistin significantly improved the number of live piglets and reduced stillbirth rates, although it also led to lighter average weights for the live-born piglets.
  • The experiment also showed that genistin increased key immune markers in the sows while potentially reducing certain cholesterol levels later in gestation, indicating it has various beneficial effects on both the sows and their litters.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!