There has been carried out histologic examination of vermicular and interosseal muscles in case of underdevelopment of fingers before and after the restoration of their length by method of distraction in 45 children aged 4-14 years. There has been stated that in case of congenital finger underdevelopment the hand muscles are subjected to hypoplasia. However they are endowed with high ability of regeneration and restore their structure in response to distraction after adequate regenerative changes.
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Virchows Arch
January 2025
Department of Pathology, Unidade Local de Saúde São João, Porto, Portugal.
This case report describes a rare case of bi-phenotypic gastric cancer with two distinct, but clonally related, histological components. The first component, associated with Epstein-Barr virus (EBV) infection, exhibited the morphological features of gastric carcinoma with lymphoid stroma, suggesting that EBV, as an effective immunogenic factor, may trigger a prominent immune response within the tumour microenvironment. The second component, which was EBV-negative, displayed tubular/papillary morphology and features of increased biological aggressiveness, such as high-grade areas and lymphatic invasion.
View Article and Find Full Text PDFGenes Chromosomes Cancer
January 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, presenting with heterogeneous clinical and molecular subtypes. While gene fusions are predominantly associated with alveolar RMS, spindle cell RMS, especially congenital and intraosseous variants, are also linked to specific gene fusions. Furthermore, recently, FGFR1 kinase-driven RMSs were published.
View Article and Find Full Text PDFIndian J Nephrol
July 2024
Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India.
The simultaneous occurrence of vasculitic glomerulonephritis and membranous nephropathy is unusual. We report two cases that presented to our outpatient department with rapidly progressive renal failure. On evaluation, in one patient, anti-myeloperoxidase (MPO) titers were high, and renal biopsy was suggestive of concurrent necrotizing and diffuse crescentic anti-MPO anti-neutrophil cytoplasmic antigen-associated glomerulonephritis with the circumferential cellular crescent formation and membranous glomerulopathy.
View Article and Find Full Text PDFCase Rep Pathol
January 2025
Cardio-Thoracic Surgery, Zhangqiu District Hospital, Jinan City, Shandong Province, China.
Myoepithelioma-like tumor of the vulvar region (MELTVR) is a rare mesenchymal tumor that typically arises in the female vulva. Here, we report a case of a 48-year-old woman who presented with a 2-year history of subcutaneous mass in the vulvar region. As the mass rapidly increased in the last 2 months, personal slight swelling pain appeared.
View Article and Find Full Text PDFMed J Armed Forces India
August 2023
Professor (Anatomy), Christian Medical College, Affiliated to the Tamilnadu Dr. MGR Medical University, Vellore, India.
Background: Fixation preserves the tissues in a close to the life-like state by preventing its autolysis and putrefaction. Formalin has long been considered the close to ideal fixative for histological studies. With the awareness of occupational hazards, a few researchers have tried phenoxetol as a secondary preservative which offered comparable histological results to that of formalin.
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