An efficient and practical synthesis of 2-((1H-indol-3-yl)(aryl)methyl)malononitriles under ultrasound irradiation.

Ultrason Sonochem

College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, No. 88, Hezuo Road, Baoding 071002, Hebei Province, PR China.

Published: April 2008

Synthesis of 2-((1H-indol-3-yl)(aryl)methyl)malononitrile via the Michael addition of indole with various arylmethylenemalononitriles was carried out in good yields using anhydrous zinc chloride as the catalyst under ultrasound irradiation.

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http://dx.doi.org/10.1016/j.ultsonch.2007.08.005DOI Listing

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