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Inborn errors of immunity (primary immunodeficiencies).
Allergy Asthma Clin Immunol
January 2025
Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.
Primary immunodeficiencies (PID), now often referred to as inborn errors of immunity (IEI), are a large heterogeneous group of disorders that result from deficiencies in immune system development and/or function. IEIs can be broadly classified as disorders of adaptive immunity (e.g.
View Article and Find Full Text PDFNon-genetic risk factors for keratoconus and its progression.
Clin Exp Optom
January 2025
Department of Ophthalmology, University of Auckland, Auckland, New Zealand.
Keratoconus is a multifaceted corneal ectatic disorder characterized by a range of genetic and environmental risk factors. While genetic predisposition significantly influences global disease prevalence rates as well as severity and progression rates, emerging evidence highlights the critical interplay between environmental factors and genetic susceptibility. This article provides a comprehensive overview of environmental risk factors implicated in the onset and progression of keratoconus.
View Article and Find Full Text PDFEarly markers of baked milk and egg tolerance in young children with IgE-mediated immediate reactions.
Eur Ann Allergy Clin Immunol
January 2025
Division of Allergy and Immunology, Department of Pediatrics, Marmara University, School of Medicine, Istanbul, Turkey.
Children with milk and egg allergies have outcomes in which, three-quarters are tolerant to baked forms of the allergenic food. Identifying predictors of tolerance to baked foods for IgE-mediated immediate-type reactions may guide the early introduction of baked allergens to diet and tolerance development. This study explores factors associated with early tolerance to baked foods.
View Article and Find Full Text PDFConstruction and validation of a nomogram model to predict bronchiolitis Mycoplasma pneumoniae pneumonia in children.
Sci Rep
December 2024
Department of Pediatrics, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China.
After the cancellation of COVID-19 epidemic control measures in 2023, cases of pediatric bronchiolitis caused by Mycoplasma pneumoniae (MP) have been reported successively, with some children experiencing residual bronchiolitis obliterans (BO). Currently, the diagnosis of bronchiolitis Mycoplasma pneumoniae pneumonia (MPP) primarily relies on high-resolution computed tomography (HRCT). To establish a predictive model for bronchiolitis MPP, a retrospective analysis was conducted.
View Article and Find Full Text PDFAdult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.
J Pers Med
December 2024
Respiratory Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
While the phenotypic diversity of childhood wheezing is well described, the subsequent life course of such phenotypes and their adult outcomes remain poorly understood. We hypothesized that different childhood wheezing phenotypes have varying longitudinal outcomes at age 26. We sought to identify factors associated with wheezing persistence, clinical remission, and new onset in adulthood.
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