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Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases.
Biomater Sci
January 2025
Department of Molecular Bioscience, The University of Texas at Austin, Austin, Texas 78712, USA.
Extracellular vesicles (EVs) are secreted by almost all cell types and contain DNA, RNA, proteins, lipids and other metabolites. EVs were initially believed to be cellular waste but now recognized for their role in cell-to-cell communication. Later, EVs from immune cells were discovered to function similarly to their parent cells, paving the way for their use as gene and drug carriers.
View Article and Find Full Text PDFRelationship between social support, functional outcomes and health-related quality of life in working-aged adults at three months after ischemic stroke: results from the FRAILTY study.
Health Qual Life Outcomes
January 2025
Department of Nursing, Faculty of Health Sciences, Palacký University, Olomouc, Czech Republic.
Background: The relationship between social support and functional outcomes and health-related quality of life (HRQoL) after ischemic stroke (IS) remains unclear, especially in working-aged patients.
Aim: To assess the relationship between perceived social support, functional outcomes, post-stroke psychosocial symptoms, and HRQoL in working-aged adults three months after IS.
Methods: A prospective and correlational design was used.
Unilateral diffuse cytotoxic oedema and crossed cerebellar diaschisis related to status epilepticus.
BMJ Case Rep
January 2025
Radiodiagnosis Department, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Postseizure brain changes on imaging are well-known facts. Many times, oedematous brain changes can mimic ischaemic stroke. Crossed cerebellar diaschisis refers to a depression in metabolism, affecting the cerebellar hemisphere due to contralateral supratentorial abnormalities.
View Article and Find Full Text PDFRole of Antidepressants in Acute Coronary Syndrome: An Evidence-Based Case Report.
Acta Med Indones
October 2024
1. Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Clinical Epidemiology in Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Background: Acute coronary syndrome (ACS) and depression are related to each other. Detection and proper treatment of these conditions can improve functional ability and quality of life. However, there is still controversy in this population regarding the use, safety, and efficacy of antidepressant pharmacotherapy.
View Article and Find Full Text PDFTreating to Capacity: A Case of Mesenteric Ischemia Complicated by Psychotic Depression.
J Acad Consult Liaison Psychiatry
January 2025
Department of Psychiatry, UMass Chan Medical School- Baystate, Springfield, MA. Electronic address:
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