Objective: To study the effect of Paeonol on PGI2, TXA2, ET and NO in diabetic rats.
Methods: Streptozocin was used on rats to make diabetic animal models. Different dosage of Paeonol were used on diabetic animal models. PGI2, TXA2, ET and NO were tested after 30 days therapy.
Results: Compared with those in the control group, the level of PGI2 increased and the contents of TXA2 and ET decreased in treatment group. Among them, the high dosage group was more obvious (P < 0.01). But the level of No Had no change.
Conclusion: Paeonol can decrease the ET and TXA2 in diabetic rats, and increase PGI2 in diabetic rats.
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