AI Article Synopsis
- The study assessed the glomerular filtration rate (GFR) using the MDRD formula in outpatients over 18 years old, analyzing serum creatinine with five different analytical systems.
- Four of the systems showed similar GFR distributions, while the Roche Hitachi system had higher technical errors and bias, leading to a significant increase in the number of patients identified with GFR < 60 ml/min per 1.73 m².
- The findings suggest that reports on serum creatinine measurements should specify their analytical quality, particularly when GFR estimates are clinically applied.
Article Abstract
The glomerular filtration rate (GFR) calculated by the MDRD formula was estimated in a population of outpatients aged over 18 years. Serum creatinine concentrations were measured, by using 5 analytical systems: Abbott Architect (n = 9054), Roche Modular (n = 22947), Roche Integra 400 (n = 2748), Roche Integra 700 (n = 8350), and Roche Hitachi (n = 20196). For 4 systems, the distribution of GFR differed little. The exception was the Roche Hitachi analytical system where TE and bias were higher than the acceptable requirements. Therefore, with this system, the proportion of outpatients with a GFR of < 60 ml/min per 1.73 m2 was twice higher than that with the use other analytical systems. Such publications should contain data on the analytical quality of measurement of serum creatinine concentrations in the range of 88 to 140 micromol/l. The estimated GFR may be clinically used provided that the performance of this test will be better than the acceptable analytical quality requirements established by the working NKDEP group.
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