The usefulness of interventional radiology (IVR) in clinical practice is well known. However, patient dose in IVR has recently been increased as a result of the prolongation of fluoroscopic time and the increased number of radiographies. We studied a simple method of calculating skin surface dose in patients who underwent transcatheter arterial embolization (TAE) for the treatment of hepatocellular carcinoma by obtaining the value of a dose area product meter attached to the digital subtraction angiography system. In 20 subjects (15 men and 5 women, aged an average of 68.2+/-7.3 years, respectively) who underwent TAE, exposure conditions (tube voltage, tube current, time, and size of image intensifier) in a time series and last value indicated on the dose area product meter were recorded. A dosimetric phantom was placed at a position the same as that of the patient for TAE, the surface dose (SD) of the phantom was measured under various exposure conditions, and SD per unit mAs (SD/mAs) was obtained. Then the skin surface dose in each subject was estimated from the values of the exposure condition and SD/mAs. A high correlation was observed between the last value (x) on the dose area product meter and the estimated skin surface dose (y) (r=0.933), and the following regression equation was derived: y=0.005x-0.589. The skin surface dose calculated using the regression equation was compared with that obtained by the method recommended by the Japan Association on Radiological Protection in Medicine (JARPM), considering the value estimated from the value of exposure conditions with SD/mAs as the gold standard. The results indicated that the error in the method using the regression equation was significantly lower than that of the JARPM method (18.3+/-14.0% and 75.5+/-66.0%, respectively, p<0.01). In conclusion, the skin surface dose in TAE could be monitored with high precision using the value of the dose area product meter by obtaining the regression formula between the value of the dose area product meter and the skin surface dose estimated with the phantom values.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.6009/jjrt.63.871 | DOI Listing |
Bioorg Chem
January 2025
Department of Chemistry, St Berchmans College (Autonomous), Changanassery, Kerala 686101, India; Centre for Theoretical and Computational Chemistry, St Berchmans College (Autonomous), Changanassery, Kerala 686101, India. Electronic address:
In this study, three novel derivatives of benzo[b]thiophene-2-carbaldehyde (BTAP1, BTAP2, and BTAP3) were successfully synthesized and comprehensively characterized using spectroscopic techniques including FTIR, UV-VIS, HNMR, and CNMR. Thermal analysis through TGA and DTA demonstrated remarkable thermal stability with a maximum threshold at 270 °C. Spectroscopic investigations revealed π → π* transitions in all compounds, attributed to the conjugated system comprising benzothiophene rings connected to bromophenyl/ aminophenyl/phenol rings via α, β-unsaturated ketone bridges.
View Article and Find Full Text PDFFront Allergy
January 2025
Laboratory for Clinical Immunology and Molecular Genetics, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
The basophil activation test (BAT) has become a major cellular test for evaluating the allergenic activity of specific IgEs. The impact of the BAT is due to the ability of blood basophil granulocytes to present IgE on the high-affinity FcRI receptor and to mirror the mast cell response that elicits an acute allergic reaction. The BAT proved to be able to identify allergic patients at risk of reacting to a low dose of the allergen and/or developing life-threatening reactions and thus can significantly improve the current management of allergic patients.
View Article and Find Full Text PDFPostepy Dermatol Alergol
December 2024
Department of Internal Medicine, Angiology and Physical Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Introduction: Diabetic foot syndrome (DFS) a severe complication of diabetes which can result in ulcers, infections, or tissue damage in the feet.
Aim: To compare the treatment effectiveness in patients with DFS using local O therapy depending on the O concentration.
Material And Methods: The study included 50 patients, 24 male and 26 female ones, in the age range between 39 and 84 years, with DFS.
Int J Pharm
January 2025
University of Applied Sciences and Arts Northwest. Switzerland, School of Life Sciences, Institute of Pharma Technology, Hofackerstr. 30 CH-4132 Muttenz, Switzerland. Electronic address:
In recent years, deep eutectic solvents (DESs) with their outstanding solubilization properties have emerged as strong candidates for oral enabling formulations of poorly soluble drugs. This study explores the use of drug-based therapeutic DESs (THEDESs) to solubilize a poorly soluble compound with the aim of providing a fixed-dose combination of two complementary therapeutic agents. Specifically, potential anticancer effects of ibuprofen (IBU) are harnessed in a novel type of THEDES to dissolve higher amounts of abiraterone acetate (AbAc), an antitumor agent.
View Article and Find Full Text PDFTrop Anim Health Prod
January 2025
Department of Agroindustrial Science and Technology, Federal University of Pelotas, Rio Grande Do Sul, Brazil.
During the harvest of Ilex paraguariensis, approximately 2-5 tons per hectare of thick stems are left on the soil surface. The outer portion of these stems, referred to as the coproduct, constitutes 30% of the total residue mass. Although this coproduct has been partially characterized in terms of its phytochemical profile, its technological applications remain unexplored.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!