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Deciphering odontogenic myxoma: the role of copy number variations as diagnostic signatures.
J Zhejiang Univ Sci B
December 2024
Department of Oral Pathology, Peking University School and Hospital of Stomatology / National Center of Stomatology / National Clinical Research Center for Oral Diseases / National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variation (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microdissection sequencing to integrate morphological features with genomic profiling. This allowed us to reveal the CNV profiles of OM and compare them with dental papilla (DP), dental follicle (DF), and odontogenic fibroma (OF) tissues.
View Article and Find Full Text PDFOdontogenic myxoma: A clinicopathological study over 15 years and immunohistochemical analysis.
Heliyon
October 2024
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Objective: and rationale: Odontogenic myxoma is an uncommon odontogenic tumor with locally aggressive behavior. The clinicopathological studies of odontogenic myxoma in Asian countries are very limited and only few studies have investigated the immunohistochemical profiles of the tumor. This study aims to investigate the clinicopathological and immunohistochemical features of odontogenic myxoma at the Faculty of Dentistry, Mahidol University over a 15-year period.
View Article and Find Full Text PDFDesign of patient-specific mandibular reconstruction plates and a hybrid scaffold.
Comput Biol Med
January 2025
3D Bioprinting Laboratory, Sabanci University Nanotechnology Research and Application Center, Istanbul, 34956, Turkiye; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, 34956, Turkiye. Electronic address:
Article Synopsis
- Managing segmental mandibular defects is complex and requires a multidisciplinary approach, as traditional methods like reconstruction plates alone may not yield optimal results for patients.* -
- The use of integrated hybrid scaffold systems, which combine various materials for better mechanical support and tissue healing, shows promise in enhancing recovery outcomes in mandibular reconstruction.* -
- A study utilized 3D modeling and finite element analysis to develop and assess new reconstruction plates and a biomimetic bone scaffold, highlighting improvements in biomechanical performance for better treatment strategies.*
Mandibular Condylar Head Regeneration Owing to Remodeling of the Costochondral Graft After Condylectomy for Odontogenic Myxoma.
J Craniofac Surg
October 2024
Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea.
Odontogenic myxoma of the mandibular condyle is a rare tumor that requires complete surgical resection because of the tendency for recurrence. The right mandibular condyle was resected to remove the myxoma. The author performed immediate condylar reconstruction using a costochondral graft (CCG), and stable temporomandibular joint (TMJ) function and occlusion were achieved.
View Article and Find Full Text PDFImmunohistochemical Evaluation of p300, H2AacK5 and H3AcK27 in Odontogenic Cysts and Tumors.
Oral Dis
October 2024
Cell Culture Laboratory, School of Dentistry, Federal University of Pará, Belém, Brazil.
The acetylation of histones H2A on lysine 5 (H2AacK5) and H3 on lysine 27 (H3AcK27) modulate several cellular mechanisms through the p300 enzyme in pathological lesions; however, their role in odontogenic lesions has not been addressed. This study aims to evaluate the immunoexpression of p300, H2AacK5, and H3AcK27 in samples of ameloblastoma (AMB) (n = 30), odontogenic keratocyst (OK) (n = 15), adenomatoid odontogenic tumor (AOT) (n = 10), odontogenic fibroma (OF) (n = 8), calcifying odontogenic cyst (COC) (n = 8), odontogenic myxoma (MIX) (n = 10), and ameloblastic fibroma (AF) (n = 06). The percentage of p300-positive cells was higher in AOT and decreased in COC, OK, AMB, AF, OF, and MIX.
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