We report a case of unusual extraintestinal yersiniosis in a 16-year-old girl with generalized microinfarctions of the bone and spleen. For the past 2 years she had been repeatedly admitted to our hospital with reactive arthritis, erythema nodosum and iridocyclitis of unknown aetiology. Ultrasound showed multiple round hypoechoic lesions in the spleen that were shown to have low T2 signal on MRI. MRI also showed disseminated nodular lesions of the skeleton that were low T1 and high T2 signal and demonstrated inhomogeneous contrast enhancement. The patient is currently in good health on low-dose nonsteroidal immunosuppressive therapy. This is a unique case of microinfarctions of the skeleton and spleen caused by a severe postinfectious autoimmune reaction following extraintestinal Yersinia enterocolitica infection.
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http://dx.doi.org/10.1007/s00247-007-0624-9 | DOI Listing |
Med Hypotheses
September 2024
Mayo Clinic Florida, 4500 San Pablo Rd. S, Jacksonville, FL 32224, USA.
Alzheimers Dement
October 2024
Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
Introduction: Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited.
Methods: Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression.
Biochem Biophys Res Commun
November 2024
Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Joint Center for Translational Medicine, Shanghai Fifth People's Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China. Electronic address:
Cerebral small vascular disease (CSVD) has a high incidence worldwide, but its pathological mechanisms remain poorly understood due to the lack of proper animal models. The current animal models of CSVD have several limitations such as high mortality rates and large-sized lesions, and thus it is urgent to develop new animal models of CSVD. Ultrasound can activate protoporphyrin to produce reactive oxygen species in a liquid environment.
View Article and Find Full Text PDFCureus
May 2024
General Medicine, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Background: Sickle cell disease (SCD) is an inherited red blood cell disorder, wherein mutation causes the substitution of glutamic acid to valine at the sixth position of the β-globin chain. These include sickle cell anemia (homozygous sickle mutation), sickle-beta thalassemia, and hemoglobin SCD. The clinical manifestations of SCD are protean.
View Article and Find Full Text PDFRadiol Case Rep
August 2024
Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiimachi, Kamigyo-ku, Kyoto, 602-8556, Japan.
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