Yersinia enterocolitica-associated generalized microinfarctions of bone and spleen in a child.

Pediatr Radiol

Paediatric Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Liebigstr 20a, Leipzig, Germany.

Published: December 2007

We report a case of unusual extraintestinal yersiniosis in a 16-year-old girl with generalized microinfarctions of the bone and spleen. For the past 2 years she had been repeatedly admitted to our hospital with reactive arthritis, erythema nodosum and iridocyclitis of unknown aetiology. Ultrasound showed multiple round hypoechoic lesions in the spleen that were shown to have low T2 signal on MRI. MRI also showed disseminated nodular lesions of the skeleton that were low T1 and high T2 signal and demonstrated inhomogeneous contrast enhancement. The patient is currently in good health on low-dose nonsteroidal immunosuppressive therapy. This is a unique case of microinfarctions of the skeleton and spleen caused by a severe postinfectious autoimmune reaction following extraintestinal Yersinia enterocolitica infection.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00247-007-0624-9DOI Listing

Publication Analysis

Top Keywords

generalized microinfarctions
8
microinfarctions bone
8
bone spleen
8
yersinia enterocolitica-associated
4
enterocolitica-associated generalized
4
spleen
4
spleen child
4
child report
4
report case
4
case unusual
4

Similar Publications

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Med Hypotheses

September 2024

Mayo Clinic Florida, 4500 San Pablo Rd. S, Jacksonville, FL 32224, USA.

Article Synopsis
  • Many risk factors for cognitive impairment can be modified, but new preventive strategies are needed.
  • The hypothesis suggests that unstable carotid plaque leads to microemboli, which cause small brain injuries that accumulate over time, ultimately resulting in cognitive decline.
  • Treating high-grade atherosclerosis through procedures like endarterectomy or stenting may improve cognitive outcomes by reducing the risk of these damaging microemboli.
View Article and Find Full Text PDF

Introduction: Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited.

Methods: Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression.

View Article and Find Full Text PDF

A rat model of cerebral small vascular disease induced by ultrasound and protoporphyrin.

Biochem Biophys Res Commun

November 2024

Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Joint Center for Translational Medicine, Shanghai Fifth People's Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China. Electronic address:

Cerebral small vascular disease (CSVD) has a high incidence worldwide, but its pathological mechanisms remain poorly understood due to the lack of proper animal models. The current animal models of CSVD have several limitations such as high mortality rates and large-sized lesions, and thus it is urgent to develop new animal models of CSVD. Ultrasound can activate protoporphyrin to produce reactive oxygen species in a liquid environment.

View Article and Find Full Text PDF

Background: Sickle cell disease (SCD) is an inherited red blood cell disorder, wherein mutation causes the substitution of glutamic acid to valine at the sixth position of the β-globin chain. These include sickle cell anemia (homozygous sickle mutation), sickle-beta thalassemia, and hemoglobin SCD. The clinical manifestations of SCD are protean.

View Article and Find Full Text PDF
Article Synopsis
  • A case of transient global amnesia occurred after administering a non-ionic iodinated contrast agent for an abdominal CT scan.
  • Follow-up MRI scans showed signs of hippocampal microinfarction and temporary cerebral vasospasm.
  • This is the first documented case highlighting the risk of arterial vasospasm related to intravenous iodinated contrast, emphasizing the need for caution among medical professionals.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!