Cyclopropanation of 3-(N,N-dibenzylamino)cyclohexene with either Zn(CH(2)I)(2)(Wittig-Furukawa reagent) or CF(3)CO(2)ZnCH(2)I (Shi's reagent) gives the corresponding syn-cyclopropane as a single diastereoisomer, whilst cyclopropanation of 3-(N-tert-butoxycarbonylamino)cyclohexene with CF(3)CO(2)ZnCH(2)I gives the corresponding anti-cyclopropane exclusively; facile N-deprotection gives access to either diastereoisomer of the trifluoroacetic acid salt of 2-aminobicyclo[4.1.0]heptane.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b711358g | DOI Listing |
Publication Analysis
Top Keywords
diastereoselective simmons-smith
4
simmons-smith cyclopropanations
4
cyclopropanations allylic
4
allylic amines
4
amines carbamates
4
carbamates cyclopropanation
4
cyclopropanation 3-nn-dibenzylaminocyclohexene
4
3-nn-dibenzylaminocyclohexene znch2i2wittig-furukawa
4
znch2i2wittig-furukawa reagent
4
reagent cf3co2znch2i
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!