Aim: The aim of this study was to compare the efficacy and tolerability of atosiban vs ritodrine administered as single-drug or as combination therapy with the COX inhibitor ketoprofen in the treatment of preterm labor and to investigate how frequent is the need for combination therapy with ketoprofen.

Methods: Ninety-one women with diagnosis of threatened preterm delivery at 24-33 weeks' gestation were enrolled in an observational case-control study. Forty-seven received IV atosiban (6.75 mg initial dose, 300 microg/min loading dose for 3 hours, 100 microg/min maintenance dose for 48-96 hours) and 44 IV ritodrine (0.05-0.3 mg/min). When response to the first drug in the first 2-4 hours was unsatisfactory, ketoprofen was added (100 mg loading dose IV and 100-150 mg maintenance dose every 12 hours) for a maximum of 48 hours.

Results: Ketoprofen was added in 51.1% of the atosiban group and 47.7% of the ritodrine group (P 0.75, not statistically significant). The percentages of women non delivered in the two groups were 85.1% vs 81.8% at 48 hours (P=0.44) and 59.6% vs 54.5% at 7 days (P=0.39). One woman treated with atosiban reported transient dyspnea at the administration of the bolus dose; 20.5% of women who received ritodrine developed tachycardia and 4.5% dyspnea (P=0.001). Neonatal mortality and morbidity were comparable in both groups and unrelated to ketoprofen exposure.

Conclusion: Atosiban efficacy was comparable to ritodrine, but with a superior safety profile. A large proportion of women in both groups required second-line ketoprofen therapy, with comparable neonatal outcomes.

Download full-text PDF

Source

Publication Analysis

Top Keywords

atosiban ritodrine
8
preterm labor
8
combination therapy
8
loading dose
8
dose hours
8
maintenance dose
8
atosiban
6
ritodrine
6
ketoprofen
6
dose
6

Similar Publications

Article Synopsis
  • The study explored how tocolytic agents affect blood glucose levels in mothers and their newborns among women with gestational diabetes mellitus (GDM) admitted for preterm labor in South Korea.
  • It involved 128 women divided into groups based on the tocolytic agent used: atosiban, ritodrine, and nifedipine, examining their maternal and neonatal glucose levels as well as the incidence of hyperglycemia and hypoglycemia.
  • Results indicated that those treated with atosiban and ritodrine had significantly higher maternal glucose levels and an increased risk of neonatal hypoglycemia compared to those treated with nifedipine.
View Article and Find Full Text PDF

Objective: To evaluate the safety and efficacy of atosiban and ritodrine in pregnant women who were hospitalized for threatened preterm labor (TPL).

Materials And Methods: Diagnosis records of preterm labor and subsequent pregnancy-related records and medical records of newborns were extracted from the Clinical Data Warehouse of the Catholic Medical Center's affiliated hospital. Since 2009, cases of preterm labor diagnosed before 34 weeks of pregnancy for first-time mothers who delivered at any one of three hospitals and who received drug treatment for more than 2 days to delay delivery were included in the dataset.

View Article and Find Full Text PDF

Objective: To explore the efficacy of Atosiban combined with Ritodrine treatment on spontaneous threatened preterm birth and its effect on platelet-activating factor (PAF) and fetal fibronectin levels.

Methods: Medical records from 120 patients with threatened preterm birth admitted to Baoji Maternal and Child Health Hospital from October 2020 to December 2021 were collected for this retrospective analysis. A total of 56 patients treated with Ritodrine alone were taken as the control group (CG), and the other 64 patients given combined treatment of Atosiban and Ritodrine were seen as the observation group (OG).

View Article and Find Full Text PDF
Article Synopsis
  • A study assessed the effectiveness of cervical cerclage combined with uterine contraction inhibitors in preventing late abortions and premature deliveries in 58 patients with cervical insufficiency.
  • The treatment successfully prolonged pregnancy duration, leading to an average delivery gestational age of about 35.9 weeks, with a success rate of 74.14%.
  • The findings suggest that effectively inhibiting uterine contractions after cervical cerclage can enhance pregnancy outcomes and improve the survival and quality of life for premature infants.
View Article and Find Full Text PDF

Objective: To investigate the efficacy of atosiban combined with ritodrine in threatened preterm labor (TPL) treatment and analysis of related risk factors of different pregnancy outcomes.

Methods: A retrospective study was conducted on the clinical data of 127 patients with TPL who were hospitalized in the Children's Hospital of Shanxi and Women's Health Center of Shanxi from January 2020 to November 2021. There from, 58 patients treated with ritodrine were seen as the control group (CG), and 69 treated with atosiban and ritodrine were regarded as the joint group (JG).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!