AI Article Synopsis
- Cisplatin is a strongly effective cancer treatment but can cause liver and heart toxicity, prompting interest in protective agents like ellagic acid.
- A study on rats showed that ellagic acid reduced harmful effects from cisplatin, as indicated by lower malondialdehyde (MDA) levels and higher antioxidant levels (glutathione, glutathione-peroxidase, and catalase).
- Histological damage to liver and heart tissues caused by cisplatin was lessened with ellagic acid, suggesting it could be beneficial to use both in chemotherapy for reducing oxidative stress.
Article Abstract
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer. High doses of cisplatin have also been known to produce hepatotoxicity, and several studies suggest that supplemental antioxidants can reduce cisplatin-induced hepatotoxicity. The present study was designed to determine the effects on the liver and heart oxidant/antioxidant system and the possible protective effects of ellagic acid on liver and heart toxicity induced by cisplatin. The control group received 0.9% saline; animals in the ellagic acid group received only ellagic acid (10 mg/kg); animals in the cisplatin group received only cisplatin (7 mg/kg); animals in cisplatin + ellagic acid group received ellagic acid for 10 days after cisplatin. The rats were killed at the end of the treatment period. Malondialdehyde (MDA) and glutathione (GSH) levels, glutathione-peroxidase (GSH-Px) and catalase (CAT) activities were determined in liver and heart tissue. While administration of cisplatin increased the MDA levels in liver and heart tissues, it decreased the GSH, GSH-Px and CAT in these samples when compared to the control group. The administration of ellagic acid to cisplatin-treated rats decreased the MDA levels, and increased GSH, GSH-Px and CAT in these samples. Cisplatin caused marked damages in the histopathological status of liver and heart tissues. These damages were ameliorated by ellagic acid administration. In conclusion, ellagic acid may be used in combination with cisplatin in chemotherapy to improve cisplatin-induced oxidative stress parameters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1742-7843.2007.00129.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A comprehensive profiling of phenolic compounds and antioxidant activities of 24 varieties of red raspberry cultivated in Northeast China.
J Food Sci
December 2024
College of Life Science, Northeast Forestry University, Harbin, China.
Red raspberries, valued for their nutrients and bioactive compounds, have broad uses in processing and healthy products. However, limited comprehensive research focused on the comparison of phenolic compounds of red raspberry, especially species cultivated in Northeast China, has been reported. This study aimed to conduct a thorough investigation of 24 red raspberry varieties in Northeast China for the first time, evaluating their phenolic compounds and antioxidant capacities.
View Article and Find Full Text PDFDesign, Synthesis, and Anti-infective Effect Against Candida albicans of A New Urolithin Derivative.
Chem Biodivers
December 2024
Changzhou University - Wujin Campus: Changzhou University, School of Pharmacy & School of Biological and Food Engineerin, No. 21, Middle Lake Road, Wujin District, Changzhou City, Jiangsu Province, 213164, Changzhou, CHINA.
Deep mucosal and organ infections caused by the infestation of Candida albicans(C.albicans) in immunocompromised patients represent a significant cause of mortality in hospitalised patients. The rise in fungal resistance is a consequence of the overuse of antibiotics.
View Article and Find Full Text PDFEllagic Acid Induces DNA Damage and Apoptosis in Cancer Stem-like Cells and Overcomes Cisplatin Resistance.
ACS Omega
December 2024
Cancer Biology & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal 700032, India.
Cancer stem cells (CSCs) are responsible for chemoresistance and tumor relapse in many solid malignancies, including lung and ovarian cancer. Ellagic acid (EA), a natural polyphenol, exhibits anticancer effects on various human malignancies. However, its impact and mechanism of action on cancer stem-like cells (CSLCs) are only partially understood.
View Article and Find Full Text PDFTurning agro-food waste into resources: Exploring the antioxidant effects of bioactive compounds bioaccessibility from digested jabuticaba tree leaf extract.
Food Chem
December 2024
In vitro and in vivo Nutritional and Toxicological Analysis Lab, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.; Bioactivity & Applications Laboratory, Department of Biological Sciences, Faculty of Science and Engineering, School of Natural Sciences, University of Limerick, Limerick, Ireland.. Electronic address:
The jabuticaba tree leaf, considered an agro-food by-product or waste, was evaluated as a potential unconventional ingredient of bioactive compounds. Its hydroalcoholic extracts were assessed for the phenolic chemical profile by LC-QQQ-MS and antioxidant capacity pre- and post-gastrointestinal digestion (i.e.
View Article and Find Full Text PDFEllagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1.
J Nat Med
December 2024
School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China.
Oxidative stress has been implicated as a causative factor for the development and progression of osteoporosis(OP). Ellagic acid (EA), a natural polyphenol, presents anti-oxidative and anti-inflammatory properties. However, EA's role and molecular mechanism in osteoblasts have not yet been elucidated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!