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Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade.
Nat Commun
December 2024
Anthropology Department, University of California Santa Cruz, Santa Cruz, CA, USA.
Strontium isotope (Sr/Sr) analysis with reference to strontium isotope landscapes (Sr isoscapes) allows reconstructing mobility and migration in archaeology, ecology, and forensics. However, despite the vast potential of research involving Sr/Sr analysis particularly in Africa, Sr isoscapes remain unavailable for the largest parts of the continent. Here, we measure the Sr/Sr ratios in 778 environmental samples from 24 African countries and combine this data with published data to model a bioavailable Sr isoscape for sub-Saharan Africa using random forest regression.
View Article and Find Full Text PDFGenetic, natal and spatial drivers of social phenotypes in wild great tits.
J Anim Ecol
December 2024
Department of Biology, Edward Grey Institute of Field Ornithology, University of Oxford, Oxford, UK.
In social animals, group dynamics profoundly influence collective behaviours, vital in processes like information sharing and predator vigilance. Disentangling the causes of individual-level variation in social behaviours is crucial for understanding the evolution of sociality. This requires the estimation of the genetic and environmental basis of these behaviours, which is challenging in uncontrolled wild populations.
View Article and Find Full Text PDFGuidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
Alzheimers Dement
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Oasis Diagnostics® Corporation, Vancouver, Washington, USA.
There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers.
View Article and Find Full Text PDFExpanding molecular and clinical spectrum of CPT1C-associated hereditary spastic paraplegia (SPG73)-a case series.
Ann Clin Transl Neurol
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Department of Neurology, Movement Disorders Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Autosomal-dominant variants in the CPT1C gene have been associated with hereditary spastic paraplegia type 73 (SPG73), which typically presents with slowly progressive lower limb weakness and spasticity and is therefore considered a pure form of hereditary spastic paraplegia. However, we report two unrelated males with novel CPT1C variants (NM_001199753.2: patient 1: c.
View Article and Find Full Text PDFA Natural Disaster Exacerbates and Redistributes Disease Risk Among Free-Ranging Macaques by Altering Social Structure.
Ecol Lett
January 2025
Department of Cellular and Molecular Biology, Harvard University, Cambridge, Massachusetts, USA.
Climate change is intensifying extreme weather events, with severe implications for ecosystem dynamics. A key behavioural mechanism whereby animals may cope with such events is by altering their social structure, which in turn could influence epidemic risk. However, how and to what extent natural disasters affect disease risk via changes in sociality remains unexplored in animal populations.
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