Objectives: The aim of this study was to assess the knowledge, acceptability and attitude towards the use of spermicides among students of University of Dar es Salaam (UDSM).
Methodology: This was a descriptive cross-sectional study conducted over four-month period among UDSM students. A random sample of students was recruited from all three university campus namely University College of Land and Architectural Studies (UCLAS), Muhimbili University College of Health Sciences (MUCHS) and Mlimani Campus (MC). Questionnaires with both closed and open end-questions were used for data collection in which knowledge, attitude, and acceptability of spermicides were determined. The collected data were analyzed using SPSS/PC+ version 10.0, 1999 computer package.
Results: A total of 300 students participated in this study, out of which 154 (513%) were females and 146 (48.7%) males. Majority of the students 276 (92%) had poor knowledge of spermicidal products, and out of these, 146 (53%) were absolutely unable to describe the use of spermicides. Ninety-three percent of the students had never used spermicides. Of those who had never used spermicides, 84 (30%) said because they used other contraceptive means, 50 (17.8%) said they are expensive, 29 (10.3%) attributed this to unavailability of the products, 3 (1.1%) to fear of "contracting" cancer and 13(4.6%) to the unreliability. Furthermore, a few who had used them didn't trust the products as ideal means of contraception.
Conclusion: The respondents had poor knowledge of spermicides. Spermicides were not accepted by the students because of the presumed side-effects, being very expensive and unreliable for contraception purpose. However, the respondents accepted spermicides usage as an ideal alternative to condom and effective means for a female-controlled method to prevent/reduce unwanted pregnancy and HIV risk. The study recommends that the Government/responsible authorities should encourage spermicides usage, particularly when coupled with microbicides, in reduction of unplanned pregnancies, sexually transmitted diseases (STDs) and HIV infection inclusive.
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Int J Pharm
January 2025
Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt. Electronic address:
Clotrimazole (CLO) is a strong antifungal drug approved to treat vaginal candidiasis (VC). Nanosponges (NSs) were developed to maintain providing CLO in a steady pattern with amplified accumulation in the vaginal mucosa. The quasi-emulsion solvent diffusion method was utilized to prepare NSs.
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Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 57 Stockholm, Sweden.
Choline-acetyltransferase (ChAT) is the key cholinergic enzyme responsible for the biosynthesis of acetylcholine (ACh), a crucial signaling molecule with both canonical neurotransmitter function and auto- and paracrine signaling activity in non-neuronal cells, such as lymphocytes and astroglia. Cholinergic dysfunction is linked to both neurodegenerative and inflammatory diseases. In this study, we investigated a serendipitous observation, namely that the catalytic rate of human recombinant ChAT (rhChAT) protein greatly differed in buffered solution in the presence and absence of Triton X-100 (TX100).
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Center of Excellence for Advanced Materials Research, King Abdulaziz University.
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Faculty of Pharmacy, Iryo Sosei University, Fukushima, Japan.
Background/aim: Breast cancer is mostly affected by estrogen, which promotes proliferation, tumorigenesis, and cancer progression. Estrogen sulfotransferase (SULT1E1) catalyzes sulfation to inactivate estrogens, whereas steroid sulfatase (STS) catalyzes estrogen sulfate hydrolysis to activate estrogens in breast cancer cells. Three major organosulfur compounds in garlic (Allium sativum L.
View Article and Find Full Text PDFVirol J
December 2024
Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, 3550, Australia.
The use of bacteriophages for therapy has increased over the last decade. While there is need for clear regulatory pathways for bacteriophage approval for mainstream use in clinical practice, practitioners and patients have been able to access bacteriophage therapy under compassionate grounds and through magistral preparations. However, there is currently no standard for purifying these bacteriophages to ensure safety, and good manufacturing practice certification may not be achieved in these emergency uses.
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