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Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.
Neuroreport
January 2025
Department of Neurology, the Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou Province, China.
Article Synopsis
- The study examined the relationship between serum levels of 25-hydroxyvitamin D, IGF-1, and beta-2 microglobulin in elderly patients with cognitive dysfunction after ischemic stroke.
- Data from 160 geriatric patients were analyzed, revealing that lower levels of 25-OH-VD and IGF-1 were linked to worse cognitive scores, while higher β2-MG levels correlated with greater cognitive decline.
- Factors such as diabetes, low education levels, age, and certain serum markers were identified as independent risk factors for developing cognitive dysfunction post-stroke, suggesting the importance of monitoring these serum levels in clinical settings.
Comparative Prognostic Value of Glomerular Filtration Rate, Serum Cystatin C, Beta-2-Microglobulin and Albuminuria for Death and Chronic Kidney Disease Progression.
J Clin Lab Anal
December 2024
Servicio de Nefrologia, Hospital Universitario de Badajoz, Universidad de Extremadura, Badajoz, Spain.
Aims: Serum creatinine and albuminuria are the core of most CKD prediction and progression risk models. Several biomarkers have been introduced to improve these results such as beta-2-microglobulin (B2M) and cystatin C (CysC). Nevertheless, few clinical comparisons of these biomarkers are available.
View Article and Find Full Text PDFIsatuximab-dexamethasone-pomalidomide combination effects on serum M protein and PFS in myeloma: Development of a joint model using phase I/II data.
CPT Pharmacometrics Syst Pharmacol
December 2024
INSERM, IAME, Université Paris Cité, Paris, France.
Article Synopsis
- * Data from 203 patients from phase I/II clinical trials were used, creating both longitudinal and PFS-specific models that were then integrated into a joint model to capture their interactions.
- * The final model indicated that serum M-protein changes correlate with PFS and validated the dosing regimen of Isa in a pivotal phase III study, supporting ongoing research and treatment approaches in multiple myeloma. *
Low Serum Beta-2 Microglobulin Level: A Possible Biomarker for Sarcopenia in the Elderly Population.
Medicina (Kaunas)
November 2024
Department of Medical Oncology, Faculty of Medicine, Çukurova University, 01250 Adana, Turkey.
: One of the most critical problems regarding sarcopenia is the difficulty of the diagnosis process. This study aimed to determine the prevalence and investigate the role of serum beta-2 microglobulin level as a biomarker for diagnosing sarcopenia. : This nested case-control study was conducted between 2023 and 2024 on 251 older adults.
View Article and Find Full Text PDFCommon laboratory results-based artificial intelligence analysis achieves accurate classification of plasma cell dyscrasias.
PeerJ
November 2024
Department of Laboratory Medicine, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Background: Plasma cell dyscrasias encompass a diverse set of disorders, where early and precise diagnosis is essential for optimizing patient outcomes. Despite advancements, current diagnostic methodologies remain underutilized in applying artificial intelligence (AI) to routine laboratory data. This study seeks to construct an AI-driven model leveraging standard laboratory parameters to enhance diagnostic accuracy and classification efficiency in plasma cell dyscrasias.
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