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Remifentanil vs. dexmedetomidine for cardiac surgery patients with noninvasive ventilation intolerance: a multicenter randomized controlled trial.
J Intensive Care
September 2024
Department of Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Article Synopsis
- The study evaluated the effectiveness and safety of remifentanil compared to dexmedetomidine in cardiac surgery patients experiencing moderate-to-severe intolerance to noninvasive ventilation (NIV).
- The results indicated that while both medications had similar mitigation rates for NIV intolerance overall, remifentanil showed a significant advantage at the 15-minute mark and had a higher odds ratio for success after accounting for time.
- Adverse effects were noted in the dexmedetomidine group, including instances of bradycardia and severe hypotension, whereas no adverse effects were reported for the remifentanil group.
Dexmedetomidine Versus Midazolam for End-of-Life Sedation and Agitation: Protocol for a Randomized Controlled Trial (The DREAMS Trial).
JMIR Res Protoc
September 2024
Graduate School of Medicine, University of Wollongong, Wollongong, Australia.
Article Synopsis
- The DREAMS trial investigated the effectiveness of dexmedetomidine versus midazolam for lighter sedation in terminally ill patients, aimed at alleviating distressing symptoms while maintaining some level of interaction with loved ones.
- Participants were adults receiving end-of-life care in Australia, who preferred lighter sedation, and were randomized to receive either drug through continuous subcutaneous infusion.
- The study assessed patients' levels of consciousness and agitation using specialized scales, and also collected comfort feedback from families and patients to evaluate the overall impact of the sedation methods.
Perioperative dexmedetomidine-induced delirium in a patient with schizophrenia: a case report.
BMC Anesthesiol
August 2024
Department of Anesthesiology, Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou University, NO.1558 North Sanhuan Road, Huzhou, 313000, China.
Background: Dexmedetomidine is a selective α2 receptor agonist with sedative, analgesic, anxiolytic, and anti-sympathetic effects. Dexmedetomidine is widely used for various surgical procedures performed under general anaesthesia and sedation in the intensive care unit. Dexmedetomidine was known to relieve or improve the symptoms of delirium.
View Article and Find Full Text PDFComparing the efficacy of adrenaline, clonidine, and dexmedetomidine in enhancing local anesthesia for impacted third molar extraction: a randomized controlled trial.
J Dent Anesth Pain Med
August 2024
Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, India.
Background: In human dentition, the most commonly impacted teeth are the mandibular third molars (M3M). The removal or extraction of these teeth often causes anxiety in patients due to the perceived pain involved in the process. Therefore, pain must be effectively managed using anesthesia.
View Article and Find Full Text PDFThe effects of dexmedetomidine on postoperative cognitive dysfunction in rats with bone fractures undergoing open reduction.
Am J Transl Res
July 2024
Department of Vascular Intervention, Affiliated Hospital of Weifang Medical University Weifang, Shandong, China.
Objective: To investigate the effects of dexmedetomidine on the cognitive dysfunction of aged rats after open tibia fracture surgery and the expression of inflammatory cytokines in the hippocampus.
Methods: A total of 45 aged healthy male Sprague Dawley rats were divided into control group, sham group, and dexmedetomidine group. The open tibia fracture surgery rat model was established, and dexmedetomidine was intraperitoneally injected before operation.
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