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Adult living-donor lobar lung transplant using a small-for-size graft.
Eur J Cardiothorac Surg
November 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Objectives: This study was designed to examine the outcomes of adult living-donor lobar lung transplants (LDLLTs) using small-for-size grafts.
Methods: A calculated graft forced vital capacity of <50% of the predicted forced vital capacity of the recipient was considered to indicate a small-for-size graft. Adult recipients (≥18 years) who underwent LDLLTs between 2008 and 2022 were included in this study.
Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking.
Chest
April 2024
Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Medicine, Università degli Studi di Milano-Bicocca, Milano, Italy.
Living donor (LD) lung transplantation (LT) represents an exceptional procedure in Western countries. However, in selected situations, it could be a source of unique advantages, besides addressing organ shortage. We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation.
View Article and Find Full Text PDFRoles and practice of living-related lobar lung transplantation.
J Thorac Dis
September 2023
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Living-donor lobar lung transplantation (LDLLT) was first performed in the USA and thereafter it was introduced in Japan in 1998 as an alternative modality to brain-dead donor lung transplantation (BDLT). Although the LDLLT procedure was employed for rapidly deteriorating patients who were hospitalized and mechanically ventilated at the time of transplantation, LDLLT demonstrated better or comparable post-transplant outcomes in comparison to BDLT. Less injured lobar grafts and a significantly shorter graft ischemic time possibly contributed to a significantly lower incidence of severe primary graft dysfunction (PGD) after LDLLT in comparison to BDLT.
View Article and Find Full Text PDFLiving-donor lobar lung transplantation.
J Heart Lung Transplant
January 2024
The Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:
Living-donor lobar lung transplantation (LDLLT) is indicated for critically ill patients who would not survive the waiting period in the case of severe brain-dead donor shortage. It is essential to confirm that potential donors are willing to donate without applying psychological pressure from others. In standard LDLLT, the right and left lower lobes donated by 2 healthy donors are implanted into the recipient under cardiopulmonary support.
View Article and Find Full Text PDF[Current Status and Problems of Living-donor Lobar Lung Transplantation].
Kyobu Geka
April 2022
Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
Living-donor lobar lung transplantation (LDLLT) has become an important life-saving option for patients with severe respiratory disorders in order to address the current severe shortage of brain-dead donor organs. Although LDLLT candidates were basically limited to critically ill patients who would require hospitalization, the long-term use of steroids, and/or mechanical respiratory support before transplantation, LDLLT provided good post-transplant outcomes, comparable to brain-dead donor lung transplantation( BDLT). In Kyoto University, the 1-, 5- and 10-year survival rates were 91%, 79% and 62% after LDLLT and 92%, 72% and 65% after BDLT, respectively.
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