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Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity.
Carbohydr Polym
January 2025
School of Biosciences, University of Sheffield, Sheffield, UK. Electronic address:
Streptococci, Lactococci and Enterococci all produce L-rhamnose-containing cell wall polysaccharides which define Lancefield serotypes and represent promising candidates for the design of glycoconjugate vaccines. The L-rhamnose containing Enterococcal Polysaccharide Antigen (EPA), produced by the opportunistic pathogen Enterococcus faecalis, plays a critical role in normal growth, division, biofilm formation, antimicrobial resistance, phage susceptibility, and innate immune evasion. Despite the critical role of this polymer in E.
View Article and Find Full Text PDFTeleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial.
Pediatr Res
September 2024
Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL, USA.
Objective: Teleneonatology, the use of telemedicine for newborn resuscitation and care, can connect experienced care providers with high-risk deliveries. In a simulated resuscitation, we hypothesized that teleneonatal resuscitation, compared to usual resuscitation, would reduce the no-flow fraction.
Study Design: This was a single-center, randomized simulation trial in which pediatric residents were randomized to teleneonatal or routine resuscitation.
Short and Mid-term Outcomes of Ductal Graft with Bilateral Pulmonary Banding in Hypoplastic Left Heart Syndrome and Variants.
Pediatr Cardiol
August 2024
Department of Cardiovascular Surgery, Acibadem Bakirkoy Hospital, Istanbul, Turkey.
This study evaluates a novel surgical technique inspired by the hybrid Norwood procedure, which involves ductal graft placement and bilateral pulmonary artery banding. This technique is designed to avoid the high-risk classical Norwood stage 1 operation and to avoid the need for first stage invasive catheter interventions and interstage catheter interventions when ductal stent placement is not feasible in developing countries with limited resources. Between June 2015 and December 2022, 14 patients with hypoplastic left heart syndrome and variants were treated using this procedure at our center.
View Article and Find Full Text PDFA Proposed Decision-Making Framework for the Translation of In-Person Clinical Care to Digital Care: Tutorial.
JMIR Med Educ
June 2024
Omada Health, San Francisco, CA, United States.
The continued demand for digital health requires that providers adapt thought processes to enable sound clinical decision-making in digital settings. Providers report that lack of training is a barrier to providing digital health care. Physical examination techniques and hands-on interventions must be adjusted in safe, reliable, and feasible ways to provide digital care, and decision-making may be impacted by modifications made to these techniques.
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