The NO-dependent mechanism of system hemodynamics reactions comprising increased system blood flow (cardiac output) and blood pressure to head-down tilting at 6, 12 and 18 degrees was studied in anaesthetized rats. Tilting of the rats with inhibited NO synthesis was shown to aggravate hypertension and elevate total peripheral resistance (TPR). Therefore, it can be concluded that NO-dependent vasodilation is involved in regulation of the arterial tone during tilting.

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