Innovation is essential to improve accessibility, effectiveness and efficiency of healthcare delivery. eHealth promises these improvements provided that it complies to essential requirements with respect to quality and patient safety. eHealth must be implemented thoughtfully to yield full benefit to the patient. However, there exists no structured framework of essential requirements to guide development, implementation and usage. The scope of application of eHealth is wide and new technology is introduced continuously. So, the framework of essential requirements must evolve as well to support and encourage innovation. The author proposes a process for continuous verification and validation of eHealth throughout development, implementation and use and a method to continuously update the framework of essential requirements.
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PLoS Pathog
January 2025
LPHI, UMR 5294 CNRS/UM-UA15 Inserm, Université de Montpellier, Montpellier, France.
A sustained blood-stage infection of the human malaria parasite P. falciparum relies on the active exit of merozoites from their host erythrocytes. During this process, named egress, the infected red blood cell undergoes sequential morphological events: the rounding-up of the surrounding parasitophorous vacuole, the disruption of the vacuole membrane and finally the rupture of the red blood cell membrane.
View Article and Find Full Text PDFJ Nephrol
January 2025
Department of Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA, USA.
The increasing prevalence of kidney failure highlights the crucial need for effective patient-physician communication to improve health-related quality of life and ensure adherence to treatment plans. This narrative review evaluates communication practices in the context of advanced kidney disease, focusing on the frameworks of shared decision-making, advanced care planning, and communication skills training among nephrologists. The findings highlight the significant gaps in patient-physician communication, particularly in the domains of advanced care planning, shared decision-making, and dialysis withdrawal.
View Article and Find Full Text PDFJ Med Syst
January 2025
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Optimizing operating room (OR) utilization is critical for enhancing hospital management and operational efficiency. Accurate surgical case duration predictions are essential for achieving this optimization. Our study aimed to refine the accuracy of these predictions beyond traditional estimation methods by developing Random Forest models tailored to specific surgical departments.
View Article and Find Full Text PDFPsychopharmacology (Berl)
January 2025
Department of Molecular Biology, Ariel University, Ariel, Israel.
Rationale: Rapid adaptation to stressful events is essential for survival and requires acute stress response and stress-coping strategy. However, the molecular mechanisms that govern this coping strategy have yet to be fully discovered.
Objectives: This study aims to investigate the effects of poly ADP-ribosylation (PARylation) on stress-coping strategies following acute stress and to identify the target genes influenced by Parp1-induced histone PARylation.
Ophthalmologie
January 2025
Zentrum für Augenheilkunde, Medizinische Fakultät und Universitätsklinikum Köln, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Background: Orbital lymphomas are the most frequently occurring malignant tumor entities in this region. They are less frequently also localized in the ocular adnexa and show a high entity-specific heterogeneity regarding the treatment and prognosis.
Objective: This article gives an overview of the heterogeneity of symptoms of orbital lymphoma and lymphoma of the ocular adnexa and focuses on new systemic options for treatment of this disease.
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