AI Article Synopsis
- The study aimed to replicate the association between C-reactive protein (CRP) gene variants and type 2 diabetes mellitus (T2DM), focusing on the rs2794521 variant in a diverse group of participants.
- A total of 629 T2DM cases and 579 controls were analyzed while evaluating seven CRP gene variants.
- The research found a significant association of the rs3093059 variant with T2DM among Whites, while results for rs2794521 in Blacks were not statistically significant, suggesting a need for further investigation on CRP gene variations and T2DM risk.
Article Abstract
Objective: C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians.
Research Design And Methods: The present investigation was conducted to replicate this previous association, and to further examine the potential association of a set of common CRP gene variants with the prevalence of T2DM in a case-control investigation. A total of 629 T2DM cases (476 Whites, and 153 Blacks), and 579 controls (481 Whites, and 98 Blacks) were examined. Seven CRP variants were evaluated: rs3093059, rs2794521, rs3091244, rs1417938, rs1800947, rs1130864, and rs1205.
Results: Using a marker-by-marker logistic regression analysis, adjusting for age, smoking, gender, and body mass index, we found an association of rs3093059 (recessive: OR, 7.01; 95% CI, 1.16-42.22; p=0.03) with T2DM in the white study population, and an association, albeit not statistically significant, of rs2794521 with T2DM in the Black study population. Moreover, further analysis using a haplotype-based analysis showed no evidence for an association of the haplotypes tested with T2DM.
Conclusion: Further studies are needed to examine the possible involvement of C-reactive protein gene variation in the pathogenesis of type 2 diabetes mellitus.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2007.08.013 | DOI Listing |
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